Detection of whitening agents in illegal cosmetics using attenuated total reflectance-infrared spectroscopy

被引：21

作者：

Deconinck, E. ^{[1
]}

Bothy, J. L. ^{[1
]}

Desmedt, B. ^{[1
,2
]}

Courselle, P. ^{[1
]}

De Beer, J. O. ^{[1
]}

机构：

[1] Sci Inst Publ Hlth WIV ISP, Sect Med Prod, Div Food Med & Consumer Safety, B-1050 Brussels, Belgium

[2] VUB, Ctr Pharmaceut Res CePhar, Dept Toxicol Dermatocosmetol & Pharmacognosy, B-1090 Brussels, Belgium

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2014年 / 98卷

关键词：

ATR-IR; Whitening agents; Illegal cosmetics; Chemometrics; Detection illegal compounds; ORTHOGONAL SIGNAL CORRECTION; PREPROCESSING METHODS; CLASSIFICATION; VALIDATION; LOTS;

D O I：

10.1016/j.jpba.2014.05.011

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Cosmetic products containing illegal whitening agents are still found on the European market. They represent a considerable risk to public health, since they are often characterised by severe side effects when used chronically. The detection of such products at customs is not always simple, due to misleading packaging and the existence of products containing only legal components. Therefore there is a need for easy to use equipment and techniques to perform an initial screening of samples. The use of attenuated total reflectance-infrared (ATR-IR) spectroscopy, combined with chemometrics, was evaluated for that purpose. It was found that the combination of ATR-IR with the simple chemometric technique k-nearest neighbours gave good results. A model was obtained in which a minimum of illegal samples was categorised as legal. The correctly classified illegal samples could be attributed to the illegal components present. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：178 / 185

页数：8

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