Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

被引：165

作者：

Kautzky, Jacob A. ^{[1
]}

Wang, Tao ^{[1
]}

Evans, Ryan W. ^{[1
]}

MacMillan, David W. C. ^{[1
]}

机构：

[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 21期

关键词：

COPPER-CATALYZED TRIFLUOROMETHYLATION; FLUORINE; ALKYLATION; RADICALS; CF3;

D O I：

10.1021/jacs.8b02650

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, alcohols, and strained ring systems. To demonstrate the broad potential of this new methodology for late-stage functionalization, we successfully converted a diverse array of carboxylic acid-bearing natural products and medicinal agents to the corresponding trifluoromethyl analogues.

引用

页码：6522 / 6526

页数：5

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