Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

被引：163
|
作者：
Kautzky, Jacob A. [1 ]
Wang, Tao [1 ]
Evans, Ryan W. [1 ]
MacMillan, David W. C. [1 ]
机构：
[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 21期
关键词：
COPPER-CATALYZED TRIFLUOROMETHYLATION; FLUORINE; ALKYLATION; RADICALS; CF3;
D O I：
10.1021/jacs.8b02650
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein we disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, alcohols, and strained ring systems. To demonstrate the broad potential of this new methodology for late-stage functionalization, we successfully converted a diverse array of carboxylic acid-bearing natural products and medicinal agents to the corresponding trifluoromethyl analogues.
引用
收藏
页码：6522 / 6526
页数：5
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