The Spectrum of Serious Infections Among Patients Receiving Immune Checkpoint Blockade for the Treatment of Melanoma

被引：236

作者：

Del Castillo, Maria ^{[1
]}

Romero, Fabian A. ^{[2
]}

Arguello, Esther ^{[2
]}

Kyi, Chrisann ^{[3
]}

Postow, Michael A. ^{[2
]}

Redelman-Sidi, Gil ^{[2
]}

机构：

[1] Jacobi Med Ctr, Dept Med, Bronx, NY USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[3] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2016年 / 63卷 / 11期

基金：

美国国家卫生研究院;

关键词：

infection; melanoma; checkpoint blockade; immunotherapy; ADVERSE EVENTS; NIVOLUMAB; IPILIMUMAB; DOCETAXEL; COLITIS;

D O I：

10.1093/cid/ciw539

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The risk of infection among patients receiving immune checkpoint blockade is unknown. We retrospectively reviewed medical records of 740 patients with melanoma who received immune checkpoint blockers. Serious infection occurred in 54 patients (7.3%). The main risk factors were receipt of corticosteroids and/or infliximab.

引用

页码：1490 / 1493

页数：4

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