LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process

被引：75

作者：

Qin, Yi ^{[1
,2
,3
]}

Zhu, Wenwei ^{[1
,3
]}

Xu, Wenyan ^{[1
,3
]}

Zhang, Bo ^{[1
,2
,3
]}

Shi, Si ^{[1
,2
,3
]}

Ji, Shunrong ^{[1
,2
,3
]}

Liu, Jiang ^{[1
,2
,3
]}

Long, Jiang ^{[1
,2
,3
]}

Liu, Chen ^{[1
,2
,3
]}

Liu, Liang ^{[1
,2
,3
]}

Xu, Jin ^{[1
,3
]}

Yu, Xianjun ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Shanghai Canc Ctr, Dept Pancreat & Hepatobiliary Surg, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

[3] Fudan Univ, Pancreat Canc Inst, Shanghai 200032, Peoples R China

来源：

CANCER LETTERS | 2014年 / 347卷 / 02期

基金：

美国国家科学基金会;

关键词：

LSD1; Pancreatic cancer; Glycolysis; HIF1; alpha; HISTONE DEMETHYLATION; EPIGENETIC BIOMARKERS; DOWN-REGULATION; E-CADHERIN; HYPOXIA; TUMOR; METASTASIS; EXPRESSION; CARCINOMA; CELLS;

D O I：

10.1016/j.canlet.2014.02.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The histone demethylase LSD1 (lysine specific demethylase 1) plays an important role in the epigenetic regulation of gene transcription. Our study investigated the role of LSD1 in pancreatic cancer and demonstrated that LSD1 was significantly up-regulated in pancreatic cancer patient tissue samples, and elevated LSD1 protein levels positively correlated with overall survival of pancreatic cancer patients. Using in vitro and in vivo models, we demonstrated that knock-down of LSD1 repressed proliferation and tumorigenicity of pancreatic cancer cells. Mechanistically, our study demonstrated that LSD1 synergized with HIFI a (hypoxia inducible factor-1 alpha) in maintaining glycolytic process, which fueled pancreatic cancer uncontrolled proliferation. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：225 / 232

页数：8

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