Polymorphisms in the TNF-α and IL-10 gene promoters and risk of psoriasis and correlation with disease severity

被引：37

作者：

Karam, Rehab A. ^{[1
]}

Zidan, Haidy E. ^{[1
]}

Khater, Mohamed Hamed ^{[2
]}

机构：

[1] Zagazig Univ, Dept Med Biochem, Fac Med, Zagazig, Egypt

[2] Zagazig Univ, Dept Dermatol, Fac Med, Zagazig, Egypt

来源：

CYTOKINE | 2014年 / 66卷 / 02期

关键词：

Psoriasis; IL-10; TNF-alpha; Polymorphisms; NECROSIS-FACTOR-ALPHA; SERUM-LEVELS; JAPANESE PATIENTS; INTERLEUKIN-10; ASSOCIATION; SUSCEPTIBILITY; CYTOKINES; VULGARIS; ARTHRITIS; REGION;

D O I：

10.1016/j.cyto.2014.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several cytokines were assumed to play an essential role in the induction and the pathogenesis of psoriasis. The aim of this work was to investigate the role of TNF-alpha-308 and IL-10-1082 polymorphisms and their serum levels in the pathogenesis of psoriasis and determine their relation to disease severity. 110 Psoriasis patients and 120 healthy volunteers were genotyped for TNF-alpha-308 and IL-10-1082 polymorphism by polymerase chain reaction. Serum level of TNF-alpha and IL-10 were measured by ELISA. Our study demonstrated an association of IL-10-1082 polymorphism and psoriasis and between TNF alpha-308 polymorphism and psoriasis disease and severity. Serum TNF alpha increased in patients, while serum IL-10 decreased in patients with significant correlation between serum TNF-alpha and psoriasis severity. These results indicated that TNF-alpha-308 and IL-10-1082 polymorphisms imparted significant risk towards the development of psoriasis. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：101 / 105

页数：5

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