Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence

被引：82

作者：

Jensen, Bjorn ^{[1
]}

Chen, Jeffrey ^{[1
]}

Furnish, Tim ^{[1
]}

Wallace, Mark ^{[1
]}

机构：

[1] Univ Calif San Diego, Ctr Pain Med, La Jolla, CA 92037 USA

来源：

CURRENT PAIN AND HEADACHE REPORTS | 2015年 / 19卷 / 10期

关键词：

Medical marijuana; Chronic pain; Cannabis; Phytocannabinoids; Endocannabinoids; Neuropathic pain; CHRONIC NEUROPATHIC PAIN; MULTIPLE-SCLEROSIS CAMS; CANNABIS-BASED MEDICINE; PHARMACOLOGICAL ACTIONS; DELTA(9)-TETRAHYDROCANNABINOL; DELTA-9-TETRAHYDROCANNABINOL; EFFICACY; PLACEBO; MORPHINE; TETRAHYDROCANNABINOL;

D O I：

10.1007/s11916-015-0524-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cannabinoid compounds include phytocannabinoids, endocannabinoids, and synthetics. The two primary phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), with CB1 receptors in the brain and peripheral tissue and CB2 receptors in the immune and hematopoietic systems. The route of delivery of cannabis is important as the bioavailability and metabolism are very different for smoking versus oral/sublingual routes. Gold standard clinical trials are limited; however, some studies have thus far shown evidence to support the use of cannabinoids for some cancer, neuropathic, spasticity, acute pain, and chronic pain conditions.

引用

页数：9

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