DNA microarray analysis of differentially expressed genes responsive to bisphenol A, an alkylphenol derivative, in an in vitro mouse Sertoli cell model

被引：16
|
作者：
Tabuchi, Y
Zhao, QL
Kondo, T
机构：
[1] Toyama Med & Pharmaceut Univ, Fac Med, Mol Genet Res Ctr, Toyama 9300194, Japan
[2] Toyama Med & Pharmaceut Univ, Fac Med, Dept Radiol Sci, Toyama 9300194, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 2002年 / 89卷 / 04期
关键词：
bisphenol A; microarray; Sertoli cell;
D O I：
10.1254/jjp.89.413
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To identify genes elicited by bisphenol A (BPA) in Sertoli cells, we carried out a microarray analysis of TTE3 cells (a mouse Sertoli cell line) treated with BPA. BPA (100, 200 and 400 muM) induced cell death concentration-dependently, with levels being 25%, 33% and 96%, respectively. Of the 1,081 genes analyzed, 3 genes showed decreased levels of expression while the remaining 10 genes showed increased levels in the cells treated with a subtoxic dose of BPA (200 muM). The expressions of six genes were confirmed by the TaqMan assay. These findings suggest that DNA microarray analysis is a useful tool for investigating the molecular mechanisms of the toxic effects of BPA in testicular cells.
引用
收藏
页码：413 / 416
页数：4
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