First Total Synthesis of (Z)-11-(2-oxopropylidene)-2,3,11,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(10H)-one

被引：15

作者：

More, Satish S. ^{[1
]}

Shanmughapriya, D. ^{[1
]}

Lingam, Y. ^{[1
]}

Patel, N. B. ^{[2
]}

机构：

[1] Dr Reddys Labs Ltd, Custom Pharmaceut Serv, Hyderabad, Andhra Pradesh, India

[2] Veer Narmad S Gujarat Univ, Dept Chem, Surat, India

来源：

SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 11期

关键词：

Aza Wittig; benzodiazepines; cyclization; cycloanthranilylproline; -diazoketone; AZA-WITTIG REACTION; AGENTS; 1,4-BENZODIAZEPINE-2,5-DIONES; DERIVATIVES; LIBRARY; DESIGN; POTENT; DC-81;

D O I：

10.1080/00397910802638537

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of naturally occurring (Z)-11-(2-oxopropylidene)-2,3,11,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(10H)-one,a unique cycloanthranilylproline derivative, has been achieved from readily available anthranilic acid in five steps.

引用

页码：2058 / 2066

页数：9

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