The Therapeutic Potential of MicroRNAs in Cancer: Illusion or Opportunity?

被引：15

作者：

Fortunato, Orazio ^{[1
]}

Iorio, Marilena V. ^{[2
]}

机构：

[1] Fdn IRCCS Ist Nazl Tumori, Dept Res, Tumor Genom Unit, Via Venezian 1, I-20133 Milan, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Dept Res, Mol Targeting Unit, Via Amadeo 42, I-20133 Milan, Italy

来源：

PHARMACEUTICALS | 2020年 / 13卷 / 12期

关键词：

microRNA; cancer; therapy; EXTRACELLULAR VESICLES; CELL; EXOSOMES; MESOTHELIOMA; MINICELLS; MIR-9;

D O I：

10.3390/ph13120438

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The functional involvement of microRNAs in human neoplasia has raised in the last years an increasing interest in the scientific community toward the potential application in clinics as therapeutic tools. Indeed, the possibility to modulate their expression to re-establish a lost equilibrium and counteract tumor growth and dissemination, and/or to improve responsiveness to standard therapies, is promising and fascinating. However, several issues need to be taken into account such as factors related to miRNA stability in the blood, tissue penetration and potential off-target effects, which might affect safety, tolerability and efficacy of an miRNA-based therapy. Here we describe the most relevant challenges related to miRNA-based therapy, review the delivery strategies exploited to date and the on-going clinical trials.

引用

页码：1 / 12

页数：12

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