Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer

被引：57

作者：

Gu, Wanjun ^{[1
]}

Shi, Junchao ^{[2
]}

Liu, Hui ^{[3
]}

Zhang, Xudong ^{[2
]}

Zhou, Jin J. ^{[4
]}

Li, Musheng ^{[5
]}

Zhou, Dandan ^{[5
]}

Li, Rui ^{[3
]}

Lv, Jingzhu ^{[3
]}

Wen, Guoxia ^{[1
]}

Zhu, Shanshan ^{[1
]}

Qi, Ting ^{[1
]}

Li, Wei ^{[6
]}

Wang, Xiaojing ^{[6
]}

Wang, Zhaohua ^{[7
]}

Zhu, Hua ^{[8
]}

Zhou, Changcheng ^{[2
]}

Knox, Kenneth S. ^{[9
]}

Wang, Ting ^{[9
]}

Chen, Qi ^{[2
]}

Qian, Zhongqing ^{[3
]}

Zhou, Tong ^{[5
]}

机构：

[1] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, 2 Sipailou, Nanjing 210096, Jiangsu, Peoples R China

[2] Univ Calif Riverside, Sch Med, Div Biomed Sci, 900 Univ Ave, Riverside, CA 92521 USA

[3] Bengbu Med Coll, Dept Lab Med, Anhui Prov Key Lab Immunol Chron Dis, Anhui Key Lab Infect & Immun, 2600 Donghaidadao, Bengbu 233003, Anhui, Peoples R China

[4] Univ Arizona, Dept Epidmiol & Biostat, Tucson, AZ 85721 USA

[5] Univ Nevada, Reno Sch Med, Dept Physiol & Cell Biol, 1664 North Virginia St, Reno, NV 89557 USA

[6] Bengbu Med Coll, Affiliated Hosp 1, Dept Respirat, Anhui Clin & Preclin Key Lab Resp Dis, Bengbu 233000, Anhui, Peoples R China

[7] Infect Dis Hosp Bengbu City, Bengbu 233000, Anhui, Peoples R China

[8] Ohio State Univ, Dept Surg, Columbus, OH 43210 USA

[9] Univ Arizona, Coll Med Phoenix, Dept Internal Med, Phoenix, AZ 85004 USA

来源：

MOLECULAR CANCER | 2020年 / 19卷 / 01期

关键词：

Lung cancer; Tuberculosis; tsRNA; rsRNA; ysRNA;

D O I：

10.1186/s12943-020-01280-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB). To identify reliable biomarkers for lung cancer screening, we leverage the recently discovered non-canonical small non-coding RNAs (i.e., tRNA-derived small RNAs [tsRNAs], rRNA-derived small RNAs [rsRNAs], and YRNA-derived small RNAs [ysRNAs]) in human peripheral blood mononuclear cells and develop a molecular signature composed of distinct ts/rs/ysRNAs (TRY-RNA). Our TRY-RNA signature precisely discriminates between control, lung cancer, and pulmonary TB subjects in both the discovery and validation cohorts and outperforms microRNA-based biomarkers, which bears the diagnostic potential for lung cancer screening.

引用

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