Copper(I)-catalyzed amination of halothiophenes with polyamines

被引：8

作者：

Anokhin, M. V. ^{[1
]}

Averin, A. D. ^{[1
]}

Panchenko, S. P. ^{[1
]}

Maloshitskaya, O. A. ^{[1
]}

Beletskaya, I. P. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119991, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 50卷 / 07期

基金：

俄罗斯基础研究基金会;

关键词：

COPPER-CATALYZED AMINATION; THIOPHENES; MECHANISM; HALIDES; ARYL; MILD;

D O I：

10.1134/S107042801407001X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper(I)-catalyzed hetarylation of a series of polyamines and of 4,7,10-trioxatridecane-1,13-diamine with halothiophenes has been studied with a view to obtaining the corresponding N,N'-dihetaryl derivatives. The target products can be obtained using both 3-iodothiophene in the presence of CuI/L-proline/EtCN or CuI/N,N-dimethylglycine/EtCN as catalytic system and 3-bromothiophene in the system CuI/2-(2-methyl-1-oxopropyl)cyclohexanone/DMF. The latter system is also suitable for the hetarylation of 4,7,10-trioxatridecane-1,13-diamine with 3-iodothiophene. In some cases, N-(thiophen-3-yl) derivatives have also been isolated.

引用

页码：923 / 927

页数：5

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