Dendrimer as nanocarrier for drug delivery

被引：837

作者：

Kesharwani, Prashant ^{[1
]}

Jain, Keerti ^{[1
]}

Jain, Narendra Kumar ^{[1
]}

机构：

[1] Dr Hari Singh Gour Cent Univ, Dept Pharmaceut Sci, Pharmaceut Res Lab, Sagar 470003, MP, India

来源：

PROGRESS IN POLYMER SCIENCE | 2014年 / 39卷 / 02期

关键词：

Dendrimer; Toxicity; PAMAM; PPI; Drug delivery; Biocompatibility; POLY(PROPYLENE IMINE) DENDRIMERS; MACROMOLECULAR CONTRAST AGENT; ATOMIC-FORCE MICROSCOPY; WALLED CARBON NANOTUBE; PAMAM DENDRIMER; IN-VITRO; POLY(AMIDOAMINE) DENDRIMERS; MAGNETIC-RESONANCE; TRANSEPITHELIAL TRANSPORT; PEPTIDE DENDRIMERS;

D O I：

10.1016/j.progpolymsci.2013.07.005

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Dendrimers are novel three dimensional, hyperbranched globular nanopolymeric architectures. Attractive features like nanoscopic size, narrow polydispersity index, excellent control over molecular structure, availability of multiple functional groups at the periphery and cavities in the interior distinguish them amongst the available polymers. Applications of dendrimers in a large variety of fields have been explored. Drug delivery scientists are especially enthusiastic about possible utility of dendrimers as drug delivery tool. Terminal functionalities provide a platform for conjugation of the drug and targeting moieties. In addition, these peripheral functional groups can be employed to tailor-make the properties of dendrimers, enhancing their versatility. The present review highlights the contribution of dendrimers in the field of nanotechnology with intent to aid the researchers in dendrimers in the field of drug delivery. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：268 / 307

页数：40

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