Dendrimer as nanocarrier for drug delivery

被引：806
作者：
Kesharwani, Prashant [1 ]
Jain, Keerti [1 ]
Jain, Narendra Kumar [1 ]
机构：
[1] Dr Hari Singh Gour Cent Univ, Dept Pharmaceut Sci, Pharmaceut Res Lab, Sagar 470003, MP, India
来源：
PROGRESS IN POLYMER SCIENCE | 2014年 / 39卷 / 02期
关键词：
Dendrimer; Toxicity; PAMAM; PPI; Drug delivery; Biocompatibility; POLY(PROPYLENE IMINE) DENDRIMERS; MACROMOLECULAR CONTRAST AGENT; ATOMIC-FORCE MICROSCOPY; WALLED CARBON NANOTUBE; PAMAM DENDRIMER; IN-VITRO; POLY(AMIDOAMINE) DENDRIMERS; MAGNETIC-RESONANCE; TRANSEPITHELIAL TRANSPORT; PEPTIDE DENDRIMERS;
D O I：
10.1016/j.progpolymsci.2013.07.005
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Dendrimers are novel three dimensional, hyperbranched globular nanopolymeric architectures. Attractive features like nanoscopic size, narrow polydispersity index, excellent control over molecular structure, availability of multiple functional groups at the periphery and cavities in the interior distinguish them amongst the available polymers. Applications of dendrimers in a large variety of fields have been explored. Drug delivery scientists are especially enthusiastic about possible utility of dendrimers as drug delivery tool. Terminal functionalities provide a platform for conjugation of the drug and targeting moieties. In addition, these peripheral functional groups can be employed to tailor-make the properties of dendrimers, enhancing their versatility. The present review highlights the contribution of dendrimers in the field of nanotechnology with intent to aid the researchers in dendrimers in the field of drug delivery. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：268 / 307
页数：40
相关论文
共 256 条
  • [11] Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparin
    Bai, Shuhua
    Thomas, Chandan
    Ahsan, Fakhrul
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2007, 96 (08) : 2090 - 2106
  • [12] Computational design principles for bioactive dendrimer based constructs as antagonists of the TLR4-MD-2-LPS complex
    Barata, Teresa
    Teo, Ian
    Lalwani, Sanjiv
    Simanek, Eric
    Zloh, Mire
    Shaunak, Sunil
    [J]. BIOMATERIALS, 2011, 32 (33) : 8702 - 8711
  • [13] Tapping mode atomic force microscopy investigation of poly(amidoamine) core-shell tecto(dendrimers) using carbon nanoprobes
    Betley, TA
    Hessler, JA
    Mecke, A
    Holl, MMB
    Orr, BG
    Uppuluri, S
    Tomalia, DA
    Baker, JR
    [J]. LANGMUIR, 2002, 18 (08) : 3127 - 3133
  • [14] Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting
    Bhadra, D
    Yadav, AK
    Bhadra, S
    Jain, NK
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2005, 295 (1-2) : 221 - 233
  • [15] A PEGylated dendritic nanoparticulate carrier of fluorouracil
    Bhadra, D
    Bhadra, S
    Jain, S
    Jain, NK
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 257 (1-2) : 111 - 124
  • [16] Dendrimers: Analytical characterization and applications
    Biricova, V.
    Laznickova, A.
    [J]. BIOORGANIC CHEMISTRY, 2009, 37 (06) : 185 - 192
  • [17] Lipid modified triblock PAMAM-based nanocarriers for siRNA drug co-delivery
    Biswas, Swati
    Deshpande, Pranali P.
    Navarro, Gemma
    Dodwadkar, Namita S.
    Torchilin, Vladimir R.
    [J]. BIOMATERIALS, 2013, 34 (04) : 1289 - 1301
  • [18] Dendrimers in drug research
    Boas, U
    Heegaard, PMH
    [J]. CHEMICAL SOCIETY REVIEWS, 2004, 33 (01) : 43 - 63
  • [19] Boas U, 2002, CHEMBIOCHEM, V3, P433, DOI 10.1002/1439-7633(20020503)3:5<433::AID-CBIC433>3.0.CO
  • [20] 2-0
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