Solid-phase synthesis of combretastatins A-4 and peptides conjugates

被引：0

作者：

Fang, Mingfeng ^{[1
]}

Lin, Zhongxiang ^{[1
]}

Lu, Guo-Yuan ^{[2
]}

Shankar, Gargh ^{[3
]}

Anamika, Jain ^{[3
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China

[2] Nanjing Univ, Dept Chem, Nanjing 210093, Jiangsu, Peoples R China

[3] Mata J Govt Girls PG Coll, Dept Chem, Indore, India

来源：

RESEARCH JOURNAL OF CHEMISTRY AND ENVIRONMENT | 2013年 / 17卷 / 12期

关键词：

Combretastatin A-4; tetrapeptide; tripeptide; solid-phase synthesis; conjugates; TYROSERLEUTIDE YSL; TRIPEPTIDE; PRODRUGS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The two novel conjugates of combretastatin A-4 (CA-4) and small active peptides (Arg-Gly-Asp-Ser and Tyr-Ser-Leu) linked by succinyl spacer as prodrugs were synthesized based on solid-phase synthesis. The total yield is 12% and 23% respectively. Both are water-soluble and expected to enhance the potency against human cancer cell.

引用

页码：9 / 11

页数：3

共 13 条

[1] Synthesis of water-soluble prodrugs of the cytotoxic agent combretastatin A4. [J].

Bedford, SB ;

Quarterman, CP ;

Rathbone, DL ;

Slack, JA ;

Griffin, RJ ;

Stevens, MFG .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (02) :157-160

[2] The synthesis, distribution, and anti-hepatic cancer activity of YSL [J].

Ding, WF ;

Zhang, JL ;

Yao, Z ;

Lu, R ;

Wu, DZ ;

Li, GF ;

Shen, ZL ;

Sun, YJ ;

Lin, G ;

Wang, C ;

Zhao, M ;

Peng, SQ .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (18) :4989-4994

[3]

KOMAZAWA H, 1993, BIOL PHARM BULL, V16, P997

[4]

Line B.B., 2005, J MED CHEM, V48, P1330

[5]

PETTIT GR, 1995, ANTI-CANCER DRUG DES, V10, P299

[6] ANTINEOPLASTIC AGENTS .124. ISOLATION, STRUCTURE, AND SYNTHESIS OF COMBRETASTATIN-A-1 AND COMBRETASATIN-B-1, POTENT NEW INHIBITORS OF MICROTUBULE ASSEMBLY, DERIVED FROM COMBRETUM-CAFFRUM [J].

PETTIT, GR ;

SINGH, SB ;

NIVEN, ML ;

HAMEL, E ;

SCHMIDT, JM .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (01) :119-131

[7]

Rohit S., 2009, SYNTHESIS-STUTTGART, V15, P2471

[8]

Thorpe Philip E., 2003, Cancer Research, V63, P1144

[9] Disrupting tumour blood vessels [J].

Tozer, GM ;

Kanthou, C ;

Baguley, BC .

NATURE REVIEWS CANCER, 2005, 5 (06) :423-435

[10]

Valantina SR, 2012, RES J CHEM ENVIRON, V16, P87

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