Kinase inhibitor ibrutinib to prevent cytokine-release syndrome after anti-CD19 chimeric antigen receptor T cells for B-cell neoplasms

被引：101

作者：

Ruella, M. ^{[1
,2
,3
]}

Kenderian, S. S. ^{[1
,2
,3
,4
]}

Shestova, O. ^{[1
,2
,3
]}

Klichinsky, M. ^{[1
,2
,5
]}

Melenhorst, J. J. ^{[1
,2
,3
]}

Wasik, M. A. ^{[2
,3
]}

Lacey, S. F. ^{[1
,2
,3
]}

June, C. H. ^{[1
,2
,3
,6
]}

Gill, S. ^{[1
,2
,4
,7
]}

机构：

[1] Univ Penn, Perelman Sch Med, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA

[2] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[3] Univ Penn, Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[4] Mayo Clin, Div Hematol, Dept Internal Med, Rochester, MN 55905 USA

[5] Univ Penn, Perelman Sch Med, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA

[6] Univ Penn, Parker Inst Canc Immunotherapy, Philadelphia, PA 19104 USA

[7] Univ Penn, Perelman Sch Med, Div Hematol Oncol, Dept Med, Philadelphia, PA 19104 USA

来源：

LEUKEMIA | 2017年 / 31卷 / 01期

关键词：

TARGETING BTK; LEUKEMIA; LYMPHOMA; ITK;

D O I：

10.1038/leu.2016.262

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：246 / 248

页数：3

共 16 条

[1]

[Anonymous], J CLIN ONCOL S

[2] Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia [J].

Byrd, John C. ;

Furman, Richard R. ;

Coutre, Steven E. ;

Flinn, Ian W. ;

Burger, Jan A. ;

Blum, Kristie A. ;

Grant, Barbara ;

Sharman, Jeff P. ;

Coleman, Morton ;

Wierda, William G. ;

Jones, Jeffrey A. ;

Zhao, Weiqiang ;

Heerema, Nyla A. ;

Johnson, Amy J. ;

Sukbuntherng, Juthamas ;

Chang, Betty Y. ;

Clow, Fong ;

Hedrick, Eric ;

Buggy, Joseph J. ;

James, Danelle F. ;

O'Brien, Susan .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (01) :32-42

[3] Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia [J].

Davila, Marco L. ;

Riviere, Isabelle ;

Wang, Xiuyan ;

Bartido, Shirley ;

Park, Jae ;

Curran, Kevin ;

Chung, Stephen S. ;

Stefanski, Jolanta ;

Borquez-Ojeda, Oriana ;

Olszewska, Malgorzata ;

Qu, Jinrong ;

Wasielewska, Teresa ;

He, Qing ;

Fink, Mitsu ;

Shinglot, Himaly ;

Youssif, Maher ;

Satter, Mark ;

Wang, Yongzeng ;

Hosey, James ;

Quintanilla, Hilda ;

Halton, Elizabeth ;

Bernal, Yvette ;

Bouhassira, Diana C. G. ;

Arcila, Maria E. ;

Gonen, Mithat ;

Roboz, Gail J. ;

Maslak, Peter ;

Douer, Dan ;

Frattini, Mark G. ;

Giralt, Sergio ;

Sadelain, Michel ;

Brentjens, Renier .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[4] Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes [J].

Dubovsky, Jason A. ;

Beckwith, Kyle A. ;

Natarajan, Gayathri ;

Woyach, Jennifer A. ;

Jaglowski, Samantha ;

Zhong, Yiming ;

Hessler, Joshua D. ;

Liu, Ta-Ming ;

Chang, Betty Y. ;

Larkin, Karilyn M. ;

Stefanovski, Matthew R. ;

Chappell, Danielle L. ;

Frissora, Frank W. ;

Smith, Lisa L. ;

Smucker, Kelly A. ;

Flynn, Joseph M. ;

Jones, Jeffrey A. ;

Andritsos, Leslie A. ;

Maddocks, Kami ;

Lehman, Amy M. ;

Furman, Richard ;

Sharman, Jeff ;

Mishra, Anjali ;

Caligiuri, Michael A. ;

Satoskar, Abhay R. ;

Buggy, Joseph J. ;

Muthusamy, Natarajan ;

Johnson, Amy J. ;

Byrd, John C. .

BLOOD, 2013, 122 (15) :2539-2549

[5] Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia [J].

Fraietta, Joseph A. ;

Beckwith, Kyle A. ;

Patel, Prachi R. ;

Ruella, Marco ;

Zheng, Zhaohui ;

Barrett, David M. ;

Lacey, Simon F. ;

Melenhorst, Jan Joseph ;

McGettigan, Shannon E. ;

Cook, Danielle R. ;

Zhang, Changfeng ;

Xu, Jun ;

Do, Priscilla ;

Hulitt, Jessica ;

Kudchodkar, Sagar B. ;

Cogdill, Alexandria P. ;

Gill, Saar ;

Porter, David L. ;

Woyach, Jennifer A. ;

Long, Meixiao ;

Johnson, Amy J. ;

Maddocks, Kami ;

Muthusamy, Natarajan ;

Levine, Bruce L. ;

June, Carl H. ;

Byrd, John C. ;

Maus, Marcela V. .

BLOOD, 2016, 127 (09) :1117-1127

[6]

Frey NV LB, 2014, AM SOC HEMATOL

[7] T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia [J].

Kalos, Michael ;

Levine, Bruce L. ;

Porter, David L. ;

Katz, Sharyn ;

Grupp, Stephan A. ;

Bagg, Adam ;

June, Carl H. .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (95)

[8] Ibrutinib antagonizes rituximab-dependent NK cell-mediated cytotoxicity [J].

Kohrt, Holbrook E. ;

Sagiv-Barfi, Idit ;

Rafiq, Sarwish ;

Herman, Sarah E. M. ;

Butchar, Jonathon P. ;

Cheney, Carolyn ;

Zhang, Xiaoli ;

Buggy, Joseph J. ;

Muthusamy, Natarajan ;

Levy, Ronald ;

Johnson, Amy J. ;

Byrd, John C. .

BLOOD, 2014, 123 (12) :1957-1960

[9] Current concepts in the diagnosis and management of cytokine release syndrome [J].

Lee, Daniel W. ;

Gardner, Rebecca ;

Porter, David L. ;

Louis, Chrystal U. ;

Ahmed, Nabil ;

Jensen, Michael ;

Grupp, Stephan A. ;

Mackall, Crystal L. .

BLOOD, 2014, 124 (02) :188-195

[10] Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia [J].

Maude, Shannon L. ;

Frey, Noelle ;

Shaw, Pamela A. ;

Aplenc, Richard ;

Barrett, David M. ;

Bunin, Nancy J. ;

Chew, Anne ;

Gonzalez, Vanessa E. ;

Zheng, Zhaohui ;

Lacey, Simon F. ;

Mahnke, Yolanda D. ;

Melenhorst, Jan J. ;

Rheingold, Susan R. ;

Shen, Angela ;

Teachey, David T. ;

Levine, Bruce L. ;

June, Carl H. ;

Porter, David L. ;

Grupp, Stephan A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (16) :1507-1517

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