Optimal radiation dose for patients with one to three lymph node positive breast cancer following breast-conserving surgery and anthracycline plus taxane-based chemotherapy: A retrospective multicenter analysis (KROG 1418)

被引：2

作者：

Kim, Haeyoung ^{[1
]}

Park, Won ^{[2
]}

Yu, Jeong Il ^{[2
]}

Choi, Doo Ho ^{[2
]}

Huh, Seung Jae ^{[2
]}

Kim, Yeon-Joo ^{[3
]}

Lee, Eun Sook ^{[3
]}

Lee, Keun Seok ^{[3
]}

Kang, Han-Sung ^{[3
]}

Park, In Hae ^{[3
]}

Shin, Kyung Hwan ^{[4
]}

Kim, Kyubo ^{[5
]}

Park, Kyung Ran ^{[5
]}

Kim, Yong Bae ^{[6
]}

Ahn, Sung Ja ^{[7
]}

Lee, Jong Hoon ^{[8
]}

Kim, Jin Hee ^{[9
]}

Chun, Mison ^{[10
]}

Lee, Hyung-Sik ^{[11
]}

Kim, Jung Soo ^{[12
]}

Lee, Jong-Young ^{[13
]}

机构：

[1] Hallym Univ, Dongtan Sacred Heart Hosp, Dept Radiat Oncol, Hwaseong, Gyeonggi, South Korea

[2] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiat Oncol, Seoul, South Korea

[3] Res Inst & Hosp, Ctr Breast Canc, Natl Canc Ctr, Goyang, South Korea

[4] Seoul Natl Univ, Coll Med, Dept Radiat Oncol, Seoul, South Korea

[5] Ewha Womans Univ, Mokdong Hosp, Sch Med, Dept Radiat Oncol, Seoul, South Korea

[6] Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Radiat Oncol, Seoul, South Korea

[7] Chonnam Natl Univ, Sch Med, Dept Radiat Oncol, Gwangju, South Korea

[8] Catholic Univ, St Vincents Hosp, Korea Coll Med, Dept Radiat Oncol, Suwon, South Korea

[9] Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Radiat Oncol, Daegu, South Korea

[10] Ajou Univ, Sch Med, Dept Radiat Oncol, Suwon, Gyeonggi, South Korea

[11] Dong A Univ, Dong A Univ Hosp, Sch Med, Dept Radiat Oncol, Busan, South Korea

[12] Chonbuk Natl Univ, Sch Med, Dept Radiat Oncol, Jeonju, Jeollabuk, South Korea

[13] Wonju Severance Christian Hosp, Dept Radiat Oncol, Wonju, Kangwon, South Korea

来源：

ONCOTARGET | 2017年 / 8卷 / 01期

关键词：

breast neoplasms; radiotherapy; dose-response relationship; prognosis; CONSERVATIVE TREATMENT; AMERICAN SOCIETY; IRRADIATION; THERAPY; RADIOTHERAPY; BOOST; RECURRENCE; RATIO;

D O I：

10.18632/oncotarget.12882

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and Purpose: This study was performed to determine optimal radiation dose in pN1 breast cancer patients who received breast conserving surgery (BCS) and anthracycline plus taxane (AT)-based chemotherapy. Materials and Methods: Retrospective chart reviews were performed in 1,147 patients who were treated between January 2006 and December 2010. The impact of radiation dose on treatment outcomes was evaluated. Results: Median follow-up time was 66 months. The 5-year rate of disease-free survival (DFS) was 93.2%. Larger tumor size (> 20 mm), positive lymphovascular invasion, high histologic grade, and high ratio of positive nodes (> 0.1) were significantly associated with inferior DFS. By using the 4 factors related to DFS, patients were categorized into high-risk (with >= 3 factors) and low-risk (with < 3 factors) groups. In the high-risk group, higher radiation dose (> 60.3 Gy(EQD2)) was significantly associated with better DFS than the lower dose (<= 60.3 Gy(EQD2)). However, the radiation dose did not impact DFS in the low-risk group. Conclusions: Dosing of radiation affects the outcome of post-BCS radiotherapy in pN1 breast cancer. Doses of over 60.3 Gy(EQD2) were associated with better outcome in the high-risk patients.

引用

页码：1796 / 1804

页数：9

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