circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

被引：300

作者：

Cheng, Zhuoan ^{[1
]}

Yu, Chengtao ^{[1
]}

Cui, Shaohua ^{[2
]}

Wang, Hui ^{[3
]}

Jin, Haojie ^{[3
]}

Wang, Cun ^{[3
]}

Li, Botai ^{[1
]}

Qin, Meilin ^{[3
]}

Yang, Chen ^{[4
]}

He, Jia ^{[3
]}

Zuo, Qiaozhu ^{[3
]}

Wang, Siying ^{[3
]}

Liu, Jun ^{[2
]}

Ye, Weidong ^{[5
]}

Lv, Yuanyuan ^{[3
]}

Zhao, Fangyu ^{[3
]}

Yao, Ming ^{[3
]}

Jiang, Liyan ^{[2
]}

Qin, Wenxin ^{[1
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes,Sch Biome, Shanghai 200032, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Resp Med, Shanghai 200030, Peoples R China

[3] Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, Sch Med, Shanghai 200032, Peoples R China

[4] Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China

[5] Shanghai Jiao Tong Univ, Dept Gen Surg, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

基金：

中国国家自然科学基金;

关键词：

CIRCULAR RNA; NONCODING RNAS; GENE-EXPRESSION; CENP-B; TRANSCRIPTION; LANDSCAPE; BIOMARKER; ABUNDANT;

D O I：

10.1038/s41467-019-11162-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore the expression profiles of circRNA and mRNA in 5 paired samples of LUSC. By analyzing the co-expression network of differentially expressed circRNAs and dysregulated mRNAs, we identify that a cell cycle-related circRNA, circTP63, is upregulated in LUSC tissues and its upregulation is correlated with larger tumor size and higher TNM stage in LUSC patients. Elevated circTP63 promotes cell proliferation both in vitro and in vivo. Mechanistically, circTP63 shares miRNA response elements with FOXM1. circTP63 competitively binds to miR-873-3p and prevents miR-873-3p to decrease the level of FOXM1, which upregulates CENPA and CENPB, and finally facilitates cell cycle progression.

引用

页数：13

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