Expression of cdk6 in head and neck squamous cell carcinoma

被引:20
作者
Poomsawat, Sopee [1 ]
Sanguansin, Sirima [2 ]
Punyasingh, Jirapa [1 ]
Vejchapipat, Paisarn [3 ]
Punyarit, Phaibul [4 ]
机构
[1] Mahidol Univ, Fac Dent, Dept Oral & Maxillofacial Pathol, Bangkok 10400, Thailand
[2] Mahidol Univ, Fac Dent, Dept Oral Biol, Bangkok 10400, Thailand
[3] Chulalongkorn Univ, Fac Med, Dept Surg, Bangkok 10330, Thailand
[4] Pramongkutklao Hosp, Army Inst Pathol, Bangkok, Thailand
关键词
Cdk6; Head and neck; Immunohistochemistry; Squamous cell carcinoma; DEPENDENT KINASE 6; PREMALIGNANT LESIONS; CDK4/6; INHIBITION; TUMOR-SUPPRESSOR; DOWN-REGULATION; BLADDER-CANCER; POOR-PROGNOSIS; ORAL-CANCER; PROLIFERATION; DIFFERENTIATION;
D O I
10.1007/s00784-015-1482-8
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Cdk6 is a key regulator during the G1/S cell cycle transition. Aberrant expression of cdk6 protein has been observed in many cancer types. However, little is known about the expression of cdk6 in head and neck squamous cell carcinoma (HNSCC) and its clinical significance. This study evaluated the expression of cdk6 in HNSCC and analyzed the relationship between cdk6 expression and clinicopathological parameters of HNSCC. Expression of cdk6 was immunohistochemically investigated in 98 HNSCCs. Nuclear and cytoplasmic positive cells were counted separately. Data were presented as the percentage of positive cells. The correlation between the percentage of positive cells and clinicopathological factors was determined. Nuclear and cytoplasmic staining for cdk6 were detected in 91 cases and 97 cases, respectively. A significant correlation was found only between the percentage of nuclear positive cells and T classification (p value = 0.0410). Tumors with high nuclear cdk6-positive cells showed a linear trend toward advanced tumor status (p value = 0.0064). Cdk6 was highly expressed in HNSCC. Tumors with high nuclear cdk6 expression tended to have advanced tumor status. These results suggest that cdk6 plays a vital role in HNSCC and is involved in tumor progression of this cancer. An increased nuclear cdk6 expression is an unfavorable factor for HNSCC. Cdk6 may serve as a therapeutic target in this cancer.
引用
收藏
页码:57 / 63
页数:7
相关论文
共 43 条
[1]   Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation [J].
An, HX ;
Beckmann, MW ;
Reifenberger, G ;
Bender, HG ;
Niederacher, D .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (01) :113-118
[2]   LINE-1 Hypomethylation, DNA Copy Number Alterations, and CDK6 Amplification in Esophageal Squamous Cell Carcinoma [J].
Baba, Yoshifumi ;
Watanabe, Masayuki ;
Murata, Asuka ;
Shigaki, Hironobu ;
Miyake, Keisuke ;
Ishimoto, Takatsugu ;
Iwatsuki, Masaaki ;
Iwagami, Shiro ;
Yoshida, Naoya ;
Oki, Eiji ;
Sakamaki, Kentaro ;
Nakao, Mitsuyoshi ;
Baba, Hideo .
CLINICAL CANCER RESEARCH, 2014, 20 (05) :1114-1124
[3]  
Barnes L, 2005, WHO CLASSIFICATION T
[4]   Drugging cell cycle kinases in cancer therapy [J].
Blagden, S ;
de Bono, J .
CURRENT DRUG TARGETS, 2005, 6 (03) :325-335
[5]   Expression of p16 in oral cancer and premalignant lesions [J].
Buajeeb, Waranun ;
Poomsawat, Sopee ;
Punyasingh, Jirapa ;
Sanguansin, Sirima .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2009, 38 (01) :104-108
[6]   MicroRNA-495 inhibits proliferation of glioblastoma multiforme cells by downregulating cyclin-dependent kinase 6 [J].
Chen, Shu-Mei ;
Chen, Hua-Chien ;
Chen, Shu-Jen ;
Huang, Chiung-Yin ;
Chen, Pin-Yuan ;
Wu, Tai-Wei Erich ;
Feng, Ly-Ying ;
Tsai, Hong-Chieh ;
Lui, Tai-Ngar ;
Hsueh, Chuen ;
Wei, Kuo-Chen .
WORLD JOURNAL OF SURGICAL ONCOLOGY, 2013, 11
[7]  
Chilosi M, 1998, AM J PATHOL, V152, P209
[8]   Overexpression of cdk4/cyclin D1, a possible mediator of apoptosis and an indicator of prognosis in human primary lung carcinoma [J].
Dobashi, Y ;
Goto, A ;
Fukayama, M ;
Abe, A ;
Ooi, A .
INTERNATIONAL JOURNAL OF CANCER, 2004, 110 (04) :532-541
[9]  
Ericson KK, 2003, MOL CANCER RES, V1, P654
[10]   miR-107 targets cyclin-dependent kinase 6 expression, induces cell cycle G1 arrest and inhibits invasion in gastric cancer cells [J].
Feng, Li ;
Xie, Yun ;
Zhang, Hao ;
Wu, Yunlin .
MEDICAL ONCOLOGY, 2012, 29 (02) :856-863