A Timeless Link Between Circadian Patterns and Disease

被引：43

作者：

Mazzoccoli, Gianluigi ^{[1
,2
]}

Laukkanen, Mikko O. ^{[3
]}

Vinciguerra, Manlio ^{[1
,2
,4
,5
,6
]}

Colangelo, Tommaso ^{[7
]}

Colantuoni, Vittorio ^{[7
]}

机构：

[1] IRCCS Casa Sollievo Sofferenza, Div Internal Med, Dept Med Sci, San Giovanni Rotondo, FG, Italy

[2] IRCCS Casa Sollievo Sofferenza, Chronobiol Unit, San Giovanni Rotondo, FG, Italy

[3] IRCCS SDN, Naples, Italy

[4] Euromediterranean Inst Sci & Technol IEMEST, Palermo, Italy

[5] Nottingham Trent Univ, Sch Sci & Technol, Nottingham, England

[6] UCL, Inst Liver & Digest Hlth, Div Med, London, England

[7] Univ Sannio, Dept Sci & Technol, Benevento, Italy

来源：

TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 01期

关键词：

TIM-TIPIN COMPLEX; DNA-REPLICATION; MAMMALIAN TIMELESS; CLOCK GENES; INTERACTING PROTEIN; EXPRESSION; CANCER; ASSOCIATION; RECOMBINATION; COORDINATION;

D O I：

10.1016/j.molmed.2015.11.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Timeless (Tim) gene, originally identified in Drosophila melanogaster and subsequently in mammals, is involved in the molecular clockwork that drives 24 h periodicity in physiology and behavior. The Tim protein is involved not only in circadian rhythmicity but also in embryonic development, cell cycle progression, DNA replication, and the DNA damage response (DDR). It is thus a multifaceted factor implicated in the maintenance of many cellular processes, tissue functions, and ultimately homeostasis of various organisms, from insects to humans. This review highlights the current knowledge of Tim functions, especially the most recent achievements, and illustrates the possible roles that this factor plays in the physiological preservation of health, as well as in the pathogenic mechanisms of related diseases.

引用

页码：68 / 81

页数：14

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