Fungal strategies for overcoming host innate immune response

被引：62

作者：

Chai, Louis Y. A. ^{[1
,2
,3
]}

Netea, Mihai G. ^{[1
,2
]}

Vonk, Alieke G. ^{[4
]}

Kullberg, Bart-Jan ^{[1
,2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Med 463, NL-6525 GA Nijmegen, Netherlands

[2] Univ Nijmegen, Ctr Infect Dis, Nijmegen, Netherlands

[3] Natl Univ Singapore Hosp, Dept Med, Singapore 117548, Singapore

[4] Univ Med Ctr Rotterdam, Dept Med Microbiol & Infect Dis, Erasmus MC, Rotterdam, Netherlands

来源：

MEDICAL MYCOLOGY | 2009年 / 47卷 / 03期

关键词：

innate immunity; escape mechanisms; Toll-like receptor; ASPERGILLUS-FUMIGATUS CONIDIA; TOLL-LIKE RECEPTOR-2; NECROSIS-FACTOR-ALPHA; BETA-GLUCAN RECEPTOR; CANDIDA-ALBICANS; TRANSCRIPTIONAL RESPONSE; INTRACELLULAR PARASITISM; PNEUMOCYSTIS-CARINII; SYSTEMIC CANDIDIASIS; DENDRITIC CELLS;

D O I：

10.1080/13693780802209082

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A successful pathogen is one that is able to effectively survive and evade detection by the host innate immune defense. Fungal pathogens have adopted strategies which evade host defense and eventually cause disease in at-risk patients. Shielding of stimulatory surface recognition molecules, shedding of decoy components, induction of anti-inflammatory signals, complement evasion and resilient survival capacity are successful evasion mechanisms employed by fungal pathogens. Understanding these complex pathways of immune evasion can potentially contribute to development of novel therapeutic strategies against fungal infections.

引用

页码：227 / 236

页数：10

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