Autoimmune autonomic ganglionopathy with Sjogren's syndrome: Significance of ganglionic acetylcholine receptor antibody and therapeutic approach

被引：17

作者：

Kondo, Takayuki ^{[1
]}

Inoue, Haruhisa ^{[1
]}

Usui, Takashi ^{[2
]}

Mimori, Tsuneyo ^{[2
]}

Tomimoto, Hidekazu ^{[1
]}

Vernino, Steven ^{[3
]}

Takahashi, Ryosuke ^{[1
]}

机构：

[1] Kyoto Univ Hosp, Dept Neurol, Kyoto 606, Japan

[2] Kyoto Univ Hosp, Dept Rheumatol & Clin Immunol, Kyoto 606, Japan

[3] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2009年 / 146卷 / 1-2期

关键词：

Ganglionic acetylcholine receptor antibody; Autoimmune autonomic ganglionopathy; Sjogren's syndrome; Prednisolone; NEUROPATHY;

D O I：

10.1016/j.autneu.2008.12.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autoimmune autonomic ganglionopathy (AAG) is a disorder defined by antibodies to the nicotinic acetylcholine receptor of the autonomic ganglia. We report two patients with chronically progressing dysautonomia with Sjogren's syndrome (SS). The first case showed elevated titer of ganglionic acetylcholine receptor (AChR) antibody and improved with oral intake of prednisolone. In contrast, the second case showed no elevation of ganglionic AChR antibody titer and had poor response to immunomodulatory therapy. These two cases indicate that chronic AAG may be treatable by immunomodulatory therapy, and have relevance to SS. (C) 2008 Elsevier B.V. All rights reserved.

引用

收藏

页码：33 / 35

页数：3

相关论文

共 10 条

[1]

CHRISTOPHER H, 2008, ARCH NEUROL-CHICAGO, V65, P213

[2] Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptor [J].

Goldstein, DS ;

Holmes, C ;

Dendi, R ;

Li, ST ;

Brentzel, S ;

Vernino, S .

CLINICAL AUTONOMIC RESEARCH, 2002, 12 (04) :281-285

[3] Autonomic dysfunction in peripheral nerve disease [J].

Low, PA ;

Vernino, S ;

Suarez, G .

MUSCLE & NERVE, 2003, 27 (06) :646-661

[4] Chronic autoimmune autonomic neuropathy responsive to immunosuppressive therapy [J].

Modoni, A. ;

Mirabella, M. ;

Madia, F. ;

Sanna, T. ;

Tonali, P. A. ;

Silvestri, G. .

NEUROLOGY, 2007, 68 (02) :161-162

[5] The wide spectrum of clinical manifestations in Sjogren's syndrome-associated neuropathy [J].

Mori, K ;

Iijima, M ;

Koike, H ;

Hattori, N ;

Tanaka, F ;

Watanabe, H ;

Katsuno, M ;

Fujita, A ;

Aiba, I ;

Ogata, A ;

Saito, T ;

Asakura, K ;

Yoshida, M ;

Hirayama, M ;

Sobue, G .

BRAIN, 2005, 128 :2518-2534

[6] Plasma exchange for primary autoimmune autonomic failure [J].

Schroeder, C ;

Vernino, S ;

Birkenfeld, AL ;

Tank, J ;

Heusser, K ;

Lipp, A ;

Benter, T ;

Lindschau, C ;

Kettritz, R ;

Luft, FC ;

Jordan, J .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (15) :1585-1590

[7] Isolated autonomic cardiovascular neuropathy in a patient with primary Sjogren syndrome: A case of successful treatment with glucocorticoid [J].

Shimoyama, M ;

Ohtahara, A ;

Okamura, T ;

Watanabe, M ;

Fujimoto, Y ;

Teshima, S ;

Takeda, S ;

Hisatome, I ;

Shigamasa, C .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2002, 324 (03) :170-172

[8] Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies [J].

Vernino, S ;

Low, PA ;

Fealey, RD ;

Stewart, JD ;

Farrugia, G ;

Lennon, VA .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (12) :847-855

[9] Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group [J].

Vitali, C ;

Bombardieri, S ;

Jonsson, R ;

Moutsopoulos, HM ;

Alexander, EL ;

Carsons, SE ;

Daniels, TE ;

Fox, PC ;

Fox, RI ;

Kassan, SS ;

Pillemer, SR ;

Talal, N ;

Weisman, MH .

ANNALS OF THE RHEUMATIC DISEASES, 2002, 61 (06) :554-558

[10] Passive transfer of Sjogren's syndrome IgG produces the pathophysiology of overactive bladder [J].

Wang, F ;

Jackson, MW ;

Maughan, V ;

Cavill, D ;

Smith, AJ ;

Waterman, SA ;

Gordon, TP .

ARTHRITIS AND RHEUMATISM, 2004, 50 (11) :3637-3645