Steroidal glycosides from the underground parts of Hosta plantaginea var japonica and their cytostatic activity on leukaemia HL-60 cells

被引：27

作者：

Mimaki, Y ^{[1
]}

Kameyama, A ^{[1
]}

Kuroda, M ^{[1
]}

Sashida, Y ^{[1
]}

Hirano, T ^{[1
]}

Oka, K ^{[1
]}

Koike, K ^{[1
]}

Nikaido, T ^{[1
]}

机构：

[1] TOHO UNIV,SCH PHARMACEUT SCI,FUNABASHI,CHIBA 274,JAPAN

来源：

PHYTOCHEMISTRY | 1997年 / 44卷 / 02期

关键词：

Hosta plantaginea var japonica; Liliaceae; steroidal glycosides; steroidal saponins; C-22-steroid glycoside; cytostatic activity; HL-60; cells;

D O I：

10.1016/S0031-9422(96)00548-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new C-22-steroid glycoside was isolated from the underground parts of Hosta plantaginea var. japonica, together with a known furostanol saponin and three known spirostanol saponins. The structure of the new steroid glycoside was characterized by spectroscopic analysis and acid-catalysed hydrolysis as 2 alpha,3 beta,16 beta-trihydroxy-5 alpha-pregn-20(21)-ene-carboxylic acid gamma-lactone 3-O-{O-beta-D-glucopyranosyl-(1-->2)-O-beta-D-glucopyranosyl-(1 -->4)-beta-D-galactopyranoside}. The isolated compounds were assayed for their cytostatic activity on leukaemia HL-60 cells. The spirostanol saponins showed cytostatic activity in a dose-dependent manner with the IC50 values ranging between 1 and 3 mu g ml(-1). Copyright (C) 1996 Elsevier Science Ltd

引用

页码：305 / 310

页数：6

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