Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis

被引：53

作者：

Badawi, Alaa ^{[1
,2
]}

Velummailum, Russanthy ^{[2
]}

Ryoo, Seung Gwan ^{[3
]}

Senthinathan, Arrani ^{[4
]}

Yaghoubi, Sahar ^{[5
]}

Vasileva, Denitsa ^{[3
]}

Ostermeier, Emma ^{[3
]}

Plishka, Mikayla ^{[3
]}

Soosaipillai, Marcel ^{[6
]}

Arora, Paul ^{[7
]}

机构：

[1] Publ Hlth Agcy Canada, Publ Hlth Risk Sci Div, Toronto, ON, Canada

[2] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada

[3] Univ Toronto, Fac Arts & Sci, Toronto, ON, Canada

[4] Mt Sinai Hlth Syst, Toronto, ON, Canada

[5] Ryerson Univ, Fac Sci, Toronto, ON, Canada

[6] Univ Waterloo, Fac Sci, Waterloo, ON, Canada

[7] Publ Hlth Agcy Canada, Infect Dis Prevent & Control Branch, Natl Microbiol Lab, Toronto, ON, Canada

来源：

PLOS ONE | 2018年 / 13卷 / 07期

关键词：

TYPE-2; DIABETES-MELLITUS; ACUTE KIDNEY INJURY; RISK-FACTORS; HEMORRHAGIC-FEVER; YELLOW-FEVER; CLINICAL-FEATURES; ADULT PATIENTS; NEUROINVASIVE DISEASE; JAPANESE ENCEPHALITIS; VASCULAR LEAKAGE;

D O I：

10.1371/journal.pone.0200200

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Flavivirus diseases such as dengue fever (DENV), West Nile virus (WNV), Zika and yellow fever represent a substantial global public health concern. Preexisting chronic conditions such as cardiovascular diseases, diabetes, obesity, and asthma were thought to predict risk of progression to severe infections. Objective We aimed to quantify the frequency of chronic comorbidities in flavivirus diseases to provide an estimate for their prevalence in severe and non-severe infections and examine whether chronic diseases contribute to the increased risk of severe viral expression. Methods We conducted a comprehensive search in PubMed, Ovid MEDLINE(R), Embase and Embase Classic and grey literature databases to identify studies reporting prevalence estimates of comorbidities in flavivirus diseases. Study quality was assessed with the risk of bias tool. Age-adjusted odds ratios (ORs) were estimated for severe infection in the presence of chronic comorbidities. Results We identified 65 studies as eligible for inclusion for DENV (47 studies) and WNV (18 studies). Obesity and overweight (i.e., BMI> 25 kg/m(2), prevalence: 24.5%, 95% CI: 18.6-31.6%), hypertension (17.1%, 13.3 - 21.8%) and diabetes (13.3%, 9.3 - 18.8%) were the most prevalent comorbidities in DENV. However, hypertension (45.0%, 39.1 - 51.0%), diabetes (24.7%, 20.2 - 29.8%) and heart diseases (25.6%, 19.5 - 32.7%) were the most prevalent in WNV.ORs of severe flavivirus diseases were about 2 to 4 in infected patients with comorbidities such as diabetes, hypertension and heart diseases. The small number of studies in JEV, YFV and Zika did not permit estimating the prevalence of comorbidities in these infections. Conclusion Higher prevalence of chronic comorbidities was found in severe cases of flavivirus diseases compared to non-severe cases. Findings of the present study may guide public health practitioners and clinicians to evaluate infection severity based on the presence of comorbidity, a critical public health measure that may avert severe disease outcome given the current dearth of clear prevention practices for some flavivirus diseases.

引用

页数：27

共 154 条

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