Shock membrane electropotential drops and limited diffusive distance of β-amyloids in cerebral neurons are detrimental enhancement to Alzheimer's diseases

Molecular physicobiochemical calculations indicated that the metallic ion binding to beta-amyloids (A beta) may induce production of hydrogen peroxide, which triggers the Ca ion redistribution from the extracellular to the intracellular compartmentation, resulting in a transient membrane electropotential drop by at least 208.06 mV. Moreover, using the Mark and Houwink empirical equation, we predicted that the diffusible distances of all A beta identities would be confined in a very tiny region within a radius less than 3.96 x 10(-4) cm in brain at 192 h after produced. Because of the inherent tendency of aggregation behaved by the A beta s, the maximum diffusion coefficient and inherent viscosity were 8.24 x 10(-15) cm(2) s(-1) and 72.15 cps for the 12 mers (40.8 kDa), the largest soluble form of ABs. Conclusively, we have quantitatively predicted that the shock membrane potential drop (Delta phi> 208.06 mV) and limited diffusible distance (<3.96 x 10(-4) cm) in the brain would contribute the major detrimental effects to the neurons in the Alzheimer's diseases. (c) 2009 Elsevier B.V. All rights reserved.