Successful Completion of Pregnancy in a Patient With Chronic Myeloid Leukemia Without Active Intervention: A Case Report and Review of the Literature

被引:33
作者
Cole, Suzanne [1 ]
Kantarjian, Hagop [1 ]
Ault, Patricia [1 ]
Cortes, Jorge E. [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Unit 428, Houston, TX 77030 USA
关键词
Chronic phase; Dasatinib; Imatinib; Teratogenicity; Thrombocytosis; CHRONIC MYELOGENOUS LEUKEMIA; INTERFERON-ALPHA THERAPY; SUCCESSFUL MANAGEMENT; IMATINIB; HYDROXYUREA; LEUKAPHERESIS;
D O I
10.3816/CLM.2009.n.064
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The management of patients with chronic myeloid leukemia (CML) during pregnancy is a matter of continued debate. We present a 21-year-old woman in whom CML was diagnosed during early pregnancy. Because the patient was asymptomatic and desired to carry the pregnancy to term while minimizing fetal exposure to medication, she was observed with no therapy for the duration of her pregnancy. The white blood cell count showed a slow downward trend throughout her pregnancy. She delivered a healthy baby and breast fed for a time before initiating therapy for CIVIL. We reviewed the published case reports of women who had a pregnancy occur in the setting of treatment with imatinib. Given the adverse effects of fetal exposure to imatinib as treatment for the mother with CML, close observation might be an option for selected patients who are diagnosed with CML while pregnant and who have minimal clinical manifestations of CML.
引用
收藏
页码:324 / 327
页数:4
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