Recent Advances in Conjugated Polymer Materials for Disease Diagnosis

被引:72
作者
Lv, Fengting [1 ]
Qiu, Tian [2 ,3 ]
Liu, Libing [1 ]
Ying, Jianming [2 ,3 ]
Wang, Shu [1 ]
机构
[1] Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
[2] Chinese Acad Med Sci, Canc Hosp, Dept Pathol, Beijing 100021, Peoples R China
[3] Peking Union Med Coll, Beijing 100021, Peoples R China
关键词
conjugated polymers; optical amplification; sensing; diagnosis; DNA METHYLATION; MUTATIONS; CANCER; NANOPARTICLES; FLUORESCENCE; POLYELECTROLYTES; DESIGN;
D O I
10.1002/smll.201501700
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The extraordinary optical amplification and light-harvesting properties of conjugated polymers impart sensing systems with higher sensitivity, which meets the primary demands of early cancer diagnosis. Recent advances in the detection of DNA methylation and mutation with polyfluorene derivatives based fluorescence resonance energy transfer (FRET) as a means to modulate fluorescent responses attest to the great promise of conjugated polymers as powerful tools for the clinical diagnosis of diseases. To facilitate the ever-changing needs of diagnosis, the development of detection approaches and FRET signal analysis are highlighted in this review. Due to their exceptional brightness, excellent photostability, and low or absent toxicity, conjugated polymers are verified as superior materials for in-vivo imaging, and provide feasibility for future clinical molecular-imaging applications. The integration of conjugated polymers with clinical research has shown profound effects on diagnosis for the early detection of disease-related biomarkers, as well as in-vivo imaging, which leads to a multidisciplinary scientific field with perspectives in both basic research and application issues.
引用
收藏
页码:696 / 705
页数:10
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