SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease

被引：22

作者：

Malancona, S

Colarusso, S

Ontoria, JM

Marchetti, A

Poma, M

Stansfield, I

Laufer, R

Di Marco, A

Taliani, M

Verdirame, M

Gonzalez-Paz, O

Matassa, VG

Narjes, F

机构：

[1] Merck Res Labs, Dept Chem, Ist Ric Biol Mol P Angeletti, I-00040 Rome, Italy

[2] Merck Res Labs, Dept Pharmacol, Ist Ric Biol Mol P Angeletti, I-00040 Rome, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 17期

关键词：

D O I：

10.1016/j.bmcl.2004.05.093

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SAR on the phenethylamide I (K-i 1.2 muM) in the P2- and the V-position led to potent inhibitors, one of which showed good exposure and low clearance when administered intramuscularly to rat. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4575 / 4579

页数：5

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