Structural analogs of umifenovir 2*. The synthesis and antiHIV activity study of new regioisomeric (trans-2-phenylcyclopropyl)-1H-indole derivatives

被引：11

作者：

Schols, Dominique ^{[1
]}

Ruchko, Evsey A. ^{[2
]}

Lavrenov, Sergey N. ^{[3
]}

Kachala, Vadim V. ^{[4
]}

Nawrozkij, Maksim B. ^{[5
]}

Babushkin, Alexandre S. ^{[5
]}

机构：

[1] Rega Inst, B-3000 Louvain, Belgium

[2] Closed Joint Stock Co Farm Synth, Moscow 111024, Russia

[3] GF Gauze Sci Res Inst New Antibiot, Moscow 119021, Russia

[4] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

[5] Volgograd State Tech Univ, 28 Lenina Ave, Volgograd 400005, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2015年 / 51卷 / 11-12期

基金：

俄罗斯基础研究基金会;

关键词：

umifenovir; conformationally restricted analogs; antiviral activity; REVERSE-TRANSCRIPTASE INHIBITORS; V OBLASTI KHINONOV; BIOLOGICAL EVALUATIONS; NENITZESCU REACTION; OXINDOLES; DESIGN; POTENT;

D O I：

10.1007/s10593-016-1807-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report new carboanalogs of umifenovir - regioisomeric derivatives of ethyl 5-hydroxy-(trans-2-phenylcyclopropyl)-1De-indole-3-carboxylate. The inhibition of HIV replication by umifenovir and its carboanalogs at micromolar concentration range has been demonstrated for the first time.

引用

页码：978 / 983

页数：6

共 19 条

[1]

Allen Jr G. R., 1973, ORG REACTIONS, V20, P385

[2] Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate [J].