Pro-tumoral functions of tumor-associated macrophage EV-miRNA

被引：18

作者：

Cocks, Alexander ^{[1
]}

Del Vecchio, Filippo ^{[1
]}

Martinez-Rodriguez, Verena ^{[1
,2
]}

Schukking, Monique ^{[1
,3
]}

Fabbri, Muller ^{[1
,4
,5
]}

机构：

[1] Univ Hawaii Canc Ctr, Canc Biol Program, Honolulu, HI 96813 USA

[2] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA

[3] Univ Hawaii Manoa, Dept Mol Biosci & Bioengn, Honolulu, HI 96822 USA

[4] Childrens Natl Hosp, Ctr Canc & Immunol Res, Washington, DC 20010 USA

[5] Childrens Natl Hosp, Ctr Canc & Immunol Res, 111 Michigan Ave NW,Suite 5206, Washington, DC 20010 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2022年 / 86卷

基金：

美国国家卫生研究院;

关键词：

Tumor -associated macrophage; Extracellular vesicle; microRNA; Tumor microenvironment; CANCER EXOSOMES; PROMOTE; MICRORNAS; CELLS; DIFFERENTIATION; POLARIZATION; METASTASIS; EXPRESSION; DELIVERY; GROWTH;

D O I：

10.1016/j.semcancer.2021.08.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are central players in cancer biology. Their relevance in cancer development, progression and resistance to therapy has been further emphasized by the discovery that they are important cargo component of extracellular vesicles (EVs), which represent a prominent means of inter-cellular communication within the tumor microenvironment (TME). This review article focuses on the interaction between cancer cells and tumor -associated macrophages (TAMs) and in particular on the pro-tumoral phenotype elicited by EV-contained miRNAs released by TAMs and transferred to cancer cells. All main hallmarks of the malignant phenotype are affected by TAM-derived vesicular miRNAs, paving the road to the identification of such miRNAs as promising upcoming novel anti-cancer agents.

引用

页码：58 / 63

页数：6

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