Brain BDNF expression as a biomarker for cognitive reserve against Alzheimer disease progression

被引：62

作者：

Beeri, Michal Schnaider ^{[1
,2
]}

Sonnen, Joshua ^{[3
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[2] Chaim Sheba Med Ctr, Joseph Sagol Neurosci Ctr, Ramat Gan, Israel

[3] Univ Utah, Med Ctr, Dept Pathol, Salt Lake City, UT USA

来源：

NEUROLOGY | 2016年 / 86卷 / 08期

关键词：

NEUROTROPHIC FACTOR BDNF; HIPPOCAMPAL NEUROGENESIS; PHYSICAL-ACTIVITY; DEMENTIA;

D O I：

10.1212/WNL.0000000000002389

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Despite great scientific efforts to find treatments for Alzheimer disease (AD), only 5 medications are marketed, with limited beneficial effects on symptoms, on a limited proportion of patients, without modification of the disease course. The prevalence of AD doubles every 5 years, reaching the alarming rate of 50% in those aged 85 years and older. In the context of the demographic trends of modern society, where the elderly are the fastest growing segment of the population, identification of new therapeutic targets that may prevent, delay, or cure AD is critically needed.

引用

页码：702 / 703

页数：2

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