Tetrabromobisphenol A (TBBPA) exhibits specific antimicrobial activity against Gram-positive bacteria without detectable resistance

被引：11
作者：
Ji, Fang [1 ]
Wang, Chang [2 ]
Wang, Huimin [2 ]
Liu, Guangliang [2 ]
Chen, Bolei [3 ]
Hu, Ligang [4 ]
Jiang, Guibin [4 ]
Song, Maoyong [4 ]
Liang, Yong [1 ,2 ,5 ]
机构：
[1] Jianghan Univ, Sch Med, Wuhan 430056, Peoples R China
[2] Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China
[3] Jianghan Univ, Inst Interdisciplinary Res, Wuhan 430056, Peoples R China
[4] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, POB 2871, Beijing 100085, Peoples R China
[5] Jianghan Univ, Key Lab Optoelect Chem Mat & Devices, Minist Educ, Wuhan 430056, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 25期
关键词：
BACILLUS-SUBTILIS; STAPHYLOCOCCUS-AUREUS; LIPOTEICHOIC ACIDS; TEICHOIC-ACIDS; EXPRESSION; PEPTIDOGLYCAN; ANTIBIOTICS; AUTOLYSIS; MECHANISM; GROWTH;
D O I：
10.1039/c7cc00613f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report here the antimicrobial ability of tetrabromobisphenol A (TBBPA) against Gram-positive bacteria without detectable resistance. Microscopy imaging and gene analysis reveal that the bacterial cell wall is the target of TBBPA. Structure-activity studies of TBBPA and its analogues relate the observed antimicrobial activity to the halogen substitution neighboring the phenolic hydroxyl group.
引用
收藏
页码：3512 / 3515
页数：4
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