High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes

被引：558

作者：

Dehghan, Abbas ^{[1
]}

van Hoek, Mandy ^{[2
]}

Sijbrands, Eric J. G. ^{[2
]}

Hofman, Albert ^{[1
]}

Witteman, Jacqueline C. M. ^{[1
]}

机构：

[1] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands

来源：

DIABETES CARE | 2008年 / 31卷 / 02期

关键词：

D O I：

10.2337/dc07-1276

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - To investigate the association between serum uric acid level and risk of type 2 diabetes. RESEARCH DESIGN AND METHODS - The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes. RESULTS - The age- and sex-adjusted hazard ratios (HRs) (95% Cls) for diabetes were 1.30 (0.96-1.76) for the second, 1.63 (1.21-2.19) for the third, and 2.83 (2.13-3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78-1.49), 1.12 (0.81-1.53), and 1.68 (1.22-2.30), respectively. CONCLUSIONS - The results of this population-based study suggest that Serum uric acid is a Strong and independent risk factor for diabetes.

引用

页码：361 / 362

页数：2

共 20 条

[1] Serum uric acid and cardiovascular disease: Recent developments, and where do they leave us? [J].

Baker, JF ;

Krishnan, E ;

Chen, L ;

Schumacher, HR .

AMERICAN JOURNAL OF MEDICINE, 2005, 118 (08) :816-826

[2] Uric acid is a risk factor for myocardial infarction and stroke - The Rotterdam Study [J].

Bos, Michiel J. ;

Koudstaal, Peter J. ;

Hofman, Albert ;

Witteman, Jacqueline C. M. ;

Breteler, Monique M. B. .

STROKE, 2006, 37 (06) :1503-1507

[3] HYPERURICEMIA AS A RISK FACTOR OF CORONARY HEART-DISEASE - THE FRAMINGHAM-STUDY [J].

BRAND, FN ;

MCGEE, DL ;

KANNEL, WB ;

STOKES, J ;

CASTELLI, WP .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1985, 121 (01) :11-18

[4] Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension [J].

Butler, R ;

Morris, AD ;

Belch, JJF ;

Hill, A ;

Struthers, AD .

HYPERTENSION, 2000, 35 (03) :746-751

[5] Genetic variation, C-reactive protein levels, and incidence of diabetes [J].

Dehghan, Abbas ;

Kardys, Isabella ;

de Maat, Moniek P. M. ;

Uitterlinden, Andre G. ;

Sijbrands, Eric J. G. ;

Bootsma, Aart H. ;

Stijnen, Theo ;

Hofman, Albert ;

Schram, Miranda T. ;

Witteman, Jacqueline C. M. .

DIABETES, 2007, 56 (03) :872-878

[6] MANAGEMENT OF ASYMPTOMATIC HYPERURICEMIA [J].

DUFFY, WB ;

SENEKJIAN, HO ;

KNIGHT, TF ;

WEINMAN, EJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1981, 246 (19) :2215-2216

[7] RELATIONSHIP BETWEEN RESISTANCE TO INSULIN-MEDIATED GLUCOSE-UPTAKE, URINARY URIC-ACID CLEARANCE, AND PLASMA URIC-ACID CONCENTRATION [J].

FACCHINI, F ;

CHEN, YDI ;

HOLLENBECK, CB ;

REAVEN, GM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 266 (21) :3008-3011

[8]

Gail DM, 2002, INTERACTIVE RISK ASS

[9]

Gavin JR, 1997, DIABETES CARE, V20, P1183

[10]

HERMAN JB, 1982, LANCET, V2, P240

← 1 2 →