Zinc accelerates dengue virus type 2-induced apoptosis in Vero cells

被引：7

作者：

Shafee, N ^{[1
]}

AbuBakar, S ^{[1
]}

机构：

[1] Univ Malaya, Fac Med, Dept Med Microbiol, Kuala Lumpur 50603, Malaysia

来源：

FEBS LETTERS | 2002年 / 524卷 / 1-3期

关键词：

apoptosis; cation; dengue; Vero; zinc;

D O I：

10.1016/S0014-5793(02)02991-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dengue virus type 2 (DENV-2) infection induced apoptotic cellular DNA fragmentation in Vero cells within 8 days of infection. The addition of high concentrations of extracellular Zn2+ but not Ca2+, Mg2+ or Mn2+ to the cell culture medium hastened the detection of apoptosis to within 4 h after infection. No apoptotic cellular DNA fragmentation was detected in the cell culture treated with Zn2+ alone or infected with heat- or ultraviolet light-inactivated DENV-2 in the presence of Zn2+. These results suggest that (i) apoptosis is induced in African green monkey kidney cells infected with live DENV-2 and (ii) the addition of high extracellular Zn2+ accelerates detection of apoptosis in the DENV-2-infected cells. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：20 / 24

页数：5

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