Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex

被引：785

作者：

Gupta, A ^{[1
]}

Wang, Y ^{[1
]}

Markram, H ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

来源：

SCIENCE | 2000年 / 287卷 / 5451期

关键词：

D O I：

10.1126/science.287.5451.273

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A puzzling feature of the neocortex is the rich array of inhibitory interneurons. Multiple neuron recordings revealed numerous electrophysiological-anatomical subclasses of neocortical gamma-aminobutyric acid-ergic (GABAergic) interneurons and three types of GABAergic synapses. The type of synapse used by each interneuron to influence its neighbors follows three functional organizing principles. These principles suggest that inhibitory synapses could shape the impact of different interneurons according to their specific spatiotemporal patterns of activity and that GABAergic interneuron and synapse diversity may enable: combinatorial inhibitory effects in the neocortex.

引用

页码：273 / 278

页数：6

共 27 条

[1]

[Anonymous], NONPARAMETRIC STAT B

[2]

CAJAL SRY, 1911, HISTOLOGY DUE SYSTEM, V2

[3]

Cauli B, 1997, J NEUROSCI, V17, P3894

[4] INTRINSIC FIRING PATTERNS OF DIVERSE NEOCORTICAL NEURONS [J].

CONNORS, BW ;

GUTNICK, MJ .

TRENDS IN NEUROSCIENCES, 1990, 13 (03) :99-104

[5] NEOCORTICAL NEURONAL DIVERSITY - CHEMICAL HETEROGENEITY REVEALED BY COLOCALIZATION STUDIES OF CLASSIC NEUROTRANSMITTERS, NEUROPEPTIDES, CALCIUM-BINDING PROTEINS, AND CELL-SURFACE MOLECULES [J].

DEFELIPE, J .

CEREBRAL CORTEX, 1993, 3 (04) :273-289

[6] A TYPE OF BASKET CELL IN SUPERFICIAL LAYERS OF THE CAT VISUAL-CORTEX - A GOLGI-ELECTRON MICROSCOPE STUDY [J].

DEFELIPE, J ;

FAIREN, A .

BRAIN RESEARCH, 1982, 244 (01) :9-16

[7] STATISTICAL-DATA ANALYSIS IN THE COMPUTER-AGE [J].

EFRON, B ;

TIBSHIRANI, R .

SCIENCE, 1991, 253 (5018) :390-395

[8] FORMS OF NON-PYRAMIDAL NEURONS IN VISUAL-CORTEX OF RAT [J].

FELDMAN, ML ;

PETERS, A .

JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 179 (04) :761-793

[9] PAIRED-PULSE FACILITATION OF IPSCS IN SLICES OF IMMATURE AND MATURE MOUSE SOMATOSENSORY NEOCORTEX [J].

FLEIDERVISH, IA ;

GUTNICK, MJ .

JOURNAL OF NEUROPHYSIOLOGY, 1995, 73 (06) :2591-2595

[10]

GUPTA A, UNPUB

← 1 2 3 →