Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles

被引：23

作者：

Tweedell, Rebecca E. ^{[1
]}

Kanneganti, Thirumala-Devi ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 11期

关键词：

NLRP3; INFLAMMASOME; ACTIVATION; CASPASES;

D O I：

10.1016/j.molmed.2020.07.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：969 / 971

页数：3

共 12 条

[1] Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) [J].

Christgen, Shelbi ;

Zheng, Min ;

Kesavardhana, Sannula ;

Karki, Rajendra ;

Malireddi, R. K. Subbarao ;

Banoth, Balaji ;

Place, David E. ;

Briard, Benoit ;

Sharma, Bhesh Raj ;

Tuladhar, Shraddha ;

Samir, Parimal ;

Burton, Amanda ;

Kanneganti, Thirumala-Devi .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 10

[2] A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases [J].

Coll, Rebecca C. ;

Robertson, Avril A. B. ;

Chae, Jae Jin ;

Higgins, Sarah C. ;

Munoz-Planillo, Raul ;

Inserra, Marco C. ;

Vetter, Irina ;

Dungan, Lara S. ;

Monks, Brian G. ;

Stutz, Andrea ;

Croker, Daniel E. ;

Butler, Mark S. ;

Haneklaus, Moritz ;

Sutton, Caroline E. ;

Nunez, Gabriel ;

Latz, Eicke ;

Kastner, Daniel L. ;

Mills, Kingston H. G. ;

Masters, Seth L. ;

Schroder, Kate ;

Cooper, Matthew A. ;

O'Neill, Luke A. J. .

NATURE MEDICINE, 2015, 21 (03) :248-+

[3] Pore-forming activity and structural autoinhibition of the gasdermin family [J].

Ding, Jingjin ;

Wang, Kun ;

Liu, Wang ;

She, Yang ;

Sun, Qi ;

Shi, Jianjin ;

Sun, Hanzi ;

Wang, Da-Cheng ;

Shao, Feng .

NATURE, 2016, 535 (7610) :111-+

[4] Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer [J].

Karki, Rajendra ;

Sharma, Bhesh Raj ;

Lee, Ein ;

Banoth, Balaji ;

Malireddi, R. K. Subbarao ;

Samir, Parimal ;

Tuladhar, Shraddha ;

Mummareddy, Harisankeerth ;

Burton, Amanda R. ;

Vogel, Peter ;

Kanneganti, Thirumala-Devi .

JCI INSIGHT, 2020, 5 (12)

[5] Diverging inflammasome signals in tumorigenesis and potential targeting [J].

Karki, Rajendra ;

Kanneganti, Thirumala-Devi .

NATURE REVIEWS CANCER, 2019, 19 (04) :197-214

[6] Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling [J].

Kayagaki, Nobuhiko ;

Stowe, Irma B. ;

Lee, Bettina L. ;

O'Rourke, Karen ;

Anderson, Keith ;

Warming, Soren ;

Cuellar, Trinna ;

Haley, Benjamin ;

Roose-Girma, Merone ;

Phung, Qui T. ;

Liu, Peter S. ;

Lill, Jennie R. ;

Li, Hong ;

Wu, Jiansheng ;

Kummerfeld, Sarah ;

Zhang, Juan ;

Lee, Wyne P. ;

Snipas, Scott J. ;

Salvesen, Guy S. ;

Morris, Lucy X. ;

Fitzgerald, Linda ;

Zhang, Yafei ;

Bertram, Edward M. ;

Goodnow, Christopher C. ;

Dixit, Vishva M. .

NATURE, 2015, 526 (7575) :666-671

[7] Glyburide inhibits the Cryopyrin/Nalp3 inflammasome [J].

Lamkanfi, Mohamed ;

Mueller, James L. ;

Vitari, Alberto C. ;

Misaghi, Shahram ;

Fedorova, Anna ;

Deshayes, Kurt ;

Lee, Wyne P. ;

Hoffman, Hal M. ;

Dixit, Vishva M. .

JOURNAL OF CELL BIOLOGY, 2009, 187 (01) :61-70

[8] Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease [J].

Malireddi, R. K. Subbarao ;

Gurung, Prajwal ;

Kesavardhana, Sannula ;

Samir, Parimal ;

Burton, Amanda ;

Mummareddy, Harisankeerth ;

Vogel, Peter ;

Pelletier, Stephane ;

Burgula, Sandeepta ;

Kanneganti, Thirumala-Devi .

JOURNAL OF EXPERIMENTAL MEDICINE, 2020, 217 (03)

[9] OLT1177, a ß-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation [J].

Marchetti, Carlo ;

Swartzwelter, Benjamin ;

Gamboni, Fabia ;

Neff, Charles P. ;

Richter, Katrin ;

Azam, Tania ;

Carta, Sonia ;

Tengesdal, Isak ;

Nemkov, Travis ;

D'Alessandro, Angelo ;

Henry, Curtis ;

Jones, Gerald S. ;

Goodrich, Scott A. ;

Laurent, Joseph P. St. ;

Jones, Terry M. ;

Scribner, Curtis L. ;

Barrow, Robert B. ;

Altman, Roy D. ;

Skouras, Damaris B. ;

Gattorno, Marco ;

Grau, Veronika ;

Janciauskiene, Sabina ;

Rubartelli, Anna ;

Joosten, Leo A. B. ;

Dinarello, Charles A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (07) :E1530-E1539

[10] The inflammasome:: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β [J].

Martinon, F ;

Burns, K ;

Tschopp, J .

MOLECULAR CELL, 2002, 10 (02) :417-426

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