Beyond the Connectome: The Dynome

被引:234
作者
Kopell, Nancy J. [1 ]
Gritton, Howard J. [2 ]
Whittington, Miles A. [3 ]
Kramer, Mark A. [1 ]
机构
[1] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA
[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[3] Univ York, Hull York Med Sch, York YO10 5DD, N Yorkshire, England
基金
英国惠康基金; 美国国家科学基金会;
关键词
RHYTHM-GENERATING MICROCIRCUITS; DEEP BRAIN-STIMULATION; GAMMA-OSCILLATIONS; PREFRONTAL CORTEX; NEURONAL OSCILLATIONS; BAND OSCILLATIONS; IN-VITRO; COMPUTATIONAL PRINCIPLES; FUNCTIONAL CONNECTIVITY; ATTENTIONAL SELECTION;
D O I
10.1016/j.neuron.2014.08.016
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The human connectome will provide a detailed mapping of the brain's connectivity, with fundamental insights for health and disease. However, further understanding of brain function and dysfunction will require an integrated framework that links brain connectivity with brain dynamics, as well as the biological details that relate this connectivity more directly to function. In this Perspective, we describe such a framework for studying the brain's "dynome'' and its relationship to cognition.
引用
收藏
页码:1319 / 1328
页数:10
相关论文
共 127 条
[1]   Rates and Rhythms: A Synergistic View of Frequency and Temporal Coding in Neuronal Networks [J].
Ainsworth, Matt ;
Lee, Shane ;
Cunningham, Mark O. ;
Traub, Roger D. ;
Kopell, Nancy J. ;
Whittington, Miles A. .
NEURON, 2012, 75 (04) :572-583
[2]   Dual Gamma Rhythm Generators Control Interlaminar Synchrony in Auditory Cortex [J].
Ainsworth, Matthew ;
Lee, Shane ;
Cunningham, Mark O. ;
Roopun, Anita K. ;
Traub, Roger D. ;
Kopell, Nancy J. ;
Whittington, Miles A. .
JOURNAL OF NEUROSCIENCE, 2011, 31 (47) :17040-17051
[3]   The Anatomical Distance of Functional Connections Predicts Brain Network Topology in Health and Schizophrenia [J].
Alexander-Bloch, Aaron F. ;
Vertes, Petra E. ;
Stidd, Reva ;
Lalonde, Francois ;
Clasen, Liv ;
Rapoport, Judith ;
Giedd, Jay ;
Bullmore, Edward T. ;
Gogtay, Nitin .
CEREBRAL CORTEX, 2013, 23 (01) :127-138
[4]   Electrophysiological correlates of sleep delta waves [J].
Amzica, F ;
Steriade, M .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1998, 107 (02) :69-83
[5]  
Anticevic Alan, 2013, Front Psychiatry, V4, P169, DOI 10.3389/fpsyt.2013.00169
[6]   Increases in Functional Connectivity between Prefrontal Cortex and Striatum during Category Learning [J].
Antzoulatos, Evan G. ;
Miller, Earl K. .
NEURON, 2014, 83 (01) :216-225
[7]   Differences between Neural Activity in Prefrontal Cortex and Striatum during Learning of Novel Abstract Categories [J].
Antzoulatos, Evan G. ;
Miller, Earl K. .
NEURON, 2011, 71 (02) :243-249
[8]   Instantaneous Modulation of Gamma Oscillation Frequency by Balancing Excitation with Inhibition [J].
Atallah, Bassam V. ;
Scanziani, Massimo .
NEURON, 2009, 62 (04) :566-577
[9]   STRUCTURAL-CHANGES ACCOMPANYING MEMORY STORAGE [J].
BAILEY, CH ;
KANDEL, ER .
ANNUAL REVIEW OF PHYSIOLOGY, 1993, 55 :397-426
[10]   From the connectome to brain function [J].
Bargmann, Cornelia I. ;
Marder, Eve .
NATURE METHODS, 2013, 10 (06) :483-490