Prion Protein Peptides as Vaccines

被引：2

作者：

Ghielmetti, M. ^{[1
]}

Vranac, T. ^{[1
]}

Serbec, V. Curin ^{[1
,2
]}

机构：

[1] Blood Transfus Ctr Slovenia, Dept Prod Diagnost Reagents & Res, SI-1000 Ljubljana, Slovenia

[2] Univ Ljubljana, Fac Chem & Chem Technol, SI-1000 Ljubljana, Slovenia

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 04期

关键词：

Prion protein; peptides; epitope prediction; immune response; vaccine; B-CELL EPITOPES; MONOCLONAL-ANTIBODIES; ANTIGENIC DETERMINANTS; IMMUNE-RESPONSES; BOVINE-PRP; T-CELLS; PREDICTION; SCRAPIE; IMMUNIZATION; ISOFORM;

D O I：

10.2174/138955709787847903

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Investigations into the immunogenicity of the prion protein are ongoing. To combat its pathological isoform without affecting the cellular protein is a challenge in prion research. We here summarize the studies in which prion protein peptides have been used for immunization, to thus determine the most immunogenic parts of the prion protein.

引用

页码：470 / 480

页数：11

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