Mechanisms of Tigecycline Resistance among Klebsiella pneumoniae Clinical Isolates

被引：77

作者：

Sheng, Zi-Ke ^{[1
,2
]}

Hu, Fupin ^{[1
,2
]}

Wang, Weixia ^{[1
,2
]}

Guo, Qinglan ^{[1
,2
]}

Chen, Zhijun ^{[1
,2
]}

Xu, Xiaogang ^{[1
,2
]}

Zhu, Demei ^{[1
,2
]}

Wang, Minggui ^{[1
,2
]}

机构：

[1] Fudan Univ, Inst Antibiot, Huashan Hosp, Shanghai 200433, Peoples R China

[2] Minist Hlth, Key Lab Clin Pharmacol Antibiot, Shanghai, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 11期

基金：

中国国家自然科学基金;

关键词：

MULTIDRUG-RESISTANCE; SUSCEPTIBILITY; RAMR; EXPRESSION; MUTATIONS; ACRAB;

D O I：

10.1128/AAC.03808-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Of 26 tigecycline-nonsusceptible Klebsiella pneumoniae (TNSKP) clinical isolates, 25 had nonsynonymous mutations in ramR and/or acrR (23 in ramR and 10 in acrR). Eight TNSKP isolates possessed overexpression of ramA, acrB, rarA, and oqxB simultaneously, while 8 and 1 TNSKP strains had upregulation of ramA and acrB and of rarA and oqxB, respectively. Thus, resistance mechanisms of 9 TNSKP isolates cannot be explained by the present pathways. This study underscores the role of RamA in TNSKP and suggests the presence of novel tigecycline resistance mechanisms.

引用

页码：6982 / 6985

页数：4

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