Temporal Association of Elevated C-Reactive Protein and Periodontal Disease in Men

Background: Most studies on the relationship between serum C-reactive protein (CRP) and periodontal disease have been cross-sectional. In this study, we investigated the temporal association between CRP and periodontal disease by following a large number of subjects for 1 year. Methods: We studied 11,162 men in Nagoya, Japan, who had an initial dental examination as part of a complete physical examination and then underwent the same examination 1 year later. For the 4,997 men without periodontal disease at baseline, logistic regression analysis was performed to examine the relationship between baseline CRP and periodontal disease 1 year later, adjusting for age, body mass index, glycosylated hemoglobin A1c level, and smoking status. Similarly, logistic regression analysis was performed to examine the relationship between periodontal disease at baseline and CRP 1 year later for the 10,376 men with normal baseline CRP, adjusting for the same confounding factors. Results: Among men without high CRP at baseline, periodontal disease at baseline correlated to CRP I year later. The odds ratio was 1.336 (95% confidence interval [CI]: 1.115 to 1.674). However, in the men without periodontal disease, no significant correlations were seen with baseline CRP or periodontal disease I year later. The odds ratio was 1.163 (95% CI: 0.894 to 1.513). Conclusion: Periodontal disease increased the risk for high serum CRP levels in men after 1 year of follow-up. J Periodontol 2009;80:734-739.