Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency

被引：115

作者：

Delavari, Samaneh ^{[1
]}

Abolhassani, Hassan ^{[1
,2
]}

Abolnezhadian, Farhad ^{[3
]}

Babaha, Fateme ^{[1
,4
]}

Iranparast, Sara ^{[5
]}

Ahanchian, Hamid ^{[6
]}

Moazzen, Nasrin ^{[6
]}

Nabavi, Mohammad ^{[7
]}

Arshi, Saba ^{[7
]}

Fallahpour, Morteza ^{[7
]}

Bemanian, Mohammad Hassan ^{[7
]}

Shokri, Sima ^{[7
]}

Momen, Tooba ^{[8
]}

Sadeghi-Shabestari, Mahnaz ^{[9
]}

Molatefi, Rasol ^{[10
]}

Shirkani, Afshin ^{[11
]}

Vosughimotlagh, Ahmad ^{[12
]}

Safarirad, Molood ^{[12
]}

Sharifzadeh, Meisam ^{[13
]}

Pashangzadeh, Salar ^{[1
]}

Salami, Fereshte ^{[1
]}

Shirmast, Paniz ^{[1
]}

Rezaei, Arezou ^{[1
]}

Shad, Tannaz Moeini ^{[1
]}

Mohraz, Minoo ^{[14
]}

Rezaei, Nima ^{[1
]}

Hammarstrom, Lennart ^{[2
]}

Yazdani, Reza ^{[1
]}

Aghamohamamdi, Asghar ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Res Ctr Primary Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran

[2] Karolinska Inst, Dept Lab Med, Div Clin Immunol, Karolinska Univ Hosp Huddinge, Stockholm, Sweden

[3] Ahvaz Jundishapur Univ Med Sci, Abuzar Childrens Hosp, Dept Pediat, Ahvaz, Iran

[4] Tarbiat Modares Univ, Fac Med Sci, Dept Immunol, Tehran, Iran

[5] Ahvaz Jundishapur Univ Med Sci, Fac Med Sci, Dept Immunol, Ahvaz, Iran

[6] Mashhad Univ Med Sci, Allergy Res Ctr, Mashhad, Razavi Khorasan, Iran

[7] Iran Univ Med Sci, Rasool E Akram Hosp, Dept Allergy & Clin Immunol, Tehran, Iran

[8] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Res Inst Primordial Prevent Noncommunicable Dis, Dept Allergy & Clin Immunol, Esfahan, Iran

[9] Tabriz Univ Med Sci, Children Hosp, Immunol Res Ctr Tabriz, TB & Lung Res Ctr Tabriz, Tabriz, Iran

[10] Ardabil Univ Med Sci, Dept Pediat, Bo Ali Childrens Hosp, Ardebil, Iran

[11] Bushehr Univ Med Sci, Sch Med, Allergy & Clin Immunol Dept, Bushehr, Iran

[12] North Khorasan Univ Med Sci, Dept Pediat, Bojnurd, Iran

[13] Univ Tehran Med Sci, Children Med Ctr, Div Pediat Crit Care, Tehran, Iran

[14] Univ Tehran Med Sci, Iranian Res Ctr HIV AIDS, Iranian Inst Reduct High Risk Behav, Tehran, Iran

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2021年 / 41卷 / 02期

关键词：

COVID-19; Primary immunodeficiency; Severe viral infection; Mortality rate; COVID-19; IMMUNITY; VARIANTS; GENETICS;

D O I：

10.1007/s10875-020-00928-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (PID) is not elucidated. The current prospective study on a national registry of PID patients showed that with only 1.23 folds higher incidence of infections, these patients present a 10-folds higher mortality rate compared to population mainly in patients with combined immunodeficiency and immune dysregulation. Therefore, further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents.

引用

页码：345 / 355

页数：11

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