Where is mTOR and what is it doing there?

被引：418

作者：

Betz, Charles ^{[1
]}

Hall, Michael N. ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

JOURNAL OF CELL BIOLOGY | 2013年 / 203卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

ENDOPLASMIC-RETICULUM MEMBRANES; SMALL GTPASE-RHEB; MAMMALIAN TARGET; TUBEROUS SCLEROSIS; RAG GTPASES; RAPAMYCIN MTOR; SUBCELLULAR-LOCALIZATION; FKBP12-RAPAMYCIN-ASSOCIATED PROTEIN; MITOCHONDRIAL LOCALIZATION; TRANSCRIPTIONAL REGULATOR;

D O I：

10.1083/jcb.201306041

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2. Each complex phosphorylates a different set of substrates to regulate cell growth. In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different organisms have reported localization of TOR to several distinct subcellular compartments. Notably, the finding that mTORC1 is localized to the lysosome has significantly enhanced our understanding of mTORC1 regulation. Subcellular localization may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.

引用

收藏

页码：563 / 574

页数：12

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