Potential effects of age-associated oxidative stress on mammalian oocytes/embryos

被引：219

作者：

Tarin, Juan J. ^{[1
,2
]}

机构：

[1] Univ Valencia, Fac Med, Dept Paediat Obstet & Gynaecol, Valencia, Spain

[2] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

MOLECULAR HUMAN REPRODUCTION | 1996年 / 2卷 / 10期

关键词：

ageing; embryo development; fertilization; mitochondria; oxidative stress;

D O I：

10.1093/molehr/2.10.717

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of 'the oxygen radical-mitochondrial injury hypothesis of ageing'. This hypothesis assumes a key role in the senescent process of oxygen radical damage to mitochondrial DNA, proteins and lipids. It is proposed that a decrease in intracellular ATP concentrations and glutathione (GSH)/glutathione disulphide (GSSG) ratio together with a concomitant increase in cytosolic Ca2+ are major factors causing the observed detrimental effects of ageing on cytoskeletal fibres, fertilization and embryo development.

引用

页码：717 / 724

页数：8

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