Potential effects of age-associated oxidative stress on mammalian oocytes/embryos

被引：217
|
作者：
Tarin, Juan J. [1 ,2 ]
机构：
[1] Univ Valencia, Fac Med, Dept Paediat Obstet & Gynaecol, Valencia, Spain
[2] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA
来源：
MOLECULAR HUMAN REPRODUCTION | 1996年 / 2卷 / 10期
关键词：
ageing; embryo development; fertilization; mitochondria; oxidative stress;
D O I：
10.1093/molehr/2.10.717
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of 'the oxygen radical-mitochondrial injury hypothesis of ageing'. This hypothesis assumes a key role in the senescent process of oxygen radical damage to mitochondrial DNA, proteins and lipids. It is proposed that a decrease in intracellular ATP concentrations and glutathione (GSH)/glutathione disulphide (GSSG) ratio together with a concomitant increase in cytosolic Ca2+ are major factors causing the observed detrimental effects of ageing on cytoskeletal fibres, fertilization and embryo development.
引用
收藏
页码：717 / 724
页数：8
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