Exploring reaction pathways for the structural rearrangements of the Mn cluster induced by water binding in the S3 state of the oxygen evolving complex of photosystem II

被引:17
作者
Isobe, Hiroshi [1 ]
Shoji, Mitsuo [2 ]
Suzuki, Takayoshi [1 ]
Shen, Jian-Ren [1 ]
Yamaguchi, Kizashi [3 ]
机构
[1] Okayama Univ, Res Inst Interdisciplinary Sci, Okayama 7008530, Japan
[2] Univ Tsukuba, Ctr Computat Sci, Tsukuba, Ibaraki 3058577, Japan
[3] Osaka Univ, Inst NanoSci Design, Toyonaka, Osaka 5600043, Japan
关键词
Photosynthesis; Water oxidation; Photosystem II; Oxygen evolving complex; Mn4CaO6; cluster; Ligand environment; SUBSTRATE WATER; SPIN-CROSSOVER; CAMN4O5; CLUSTER; ACTIVE-SITE; TRANSITION; MECHANISM; OXIDATION; EXCHANGE; ELECTRON; EVOLUTION;
D O I
10.1016/j.jphotochem.2020.112905
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Photosynthetic oxidation of water to dioxygen is catalyzed by the Mn4CaO5 cluster in the protein-cofactor complex photosystem II. The light-driven catalytic cycle consists of four observable intermediates (S-0, S-1, S-2, and S-3) and one transient S-4 state. Recently, using X-ray free-electron laser crystallography, two experimental groups independently observed incorporation of one additional oxygen into the cluster during the S-2 to S-3 transition, which is likely to represent a substrate. The present study implicates two competing reaction routes encountered during the structural rearrangement of the catalyst induced by the water binding and immediately preceding the formation of final stable forms in the S-3 state. This mutually exclusive competition involves concerted versus stepwise conformational changes between two isomers, called open and closed cubane structures, which have different consequences on the immediate product in the S-3 state. The concerted pathway involves a one-step conversion between two isomeric hydroxo forms without changes to the metal oxidation and total spin (S-total = 3) states. Alternatively, in the stepwise process, the bound waters are oxidized and transformed into an oxyl-oxo form in a higher spin (S-total = 6) state. Here, density functional calculations are used to characterize all relevant intermediates and transition structures and demonstrate that the stepwise pathway to the substrate activation is substantially favored over the concerted one, as evidenced by comparison of the activation barriers (11.1 and 20.9 kcal mol(-1), respectively). Only after formation of the oxyl-oxo precursor can the hydroxo species be generated; this occurs with a slow kinetics and an activation barrier of 17.8 kcal mol(-1). The overall thermodynamic driving force is likely to be controlled by the movements of two glutamate ligands, D1-Glu189 and CP43-Glu354, in the active site and ranges from very weak (+0.4 kcal mol(-1)) to very strong (-23.5 kcal mol(-1)).
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页数:14
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