Protein tyrosine phosphatases: from genes, to function, to disease

被引：1263
|
作者：
Tonks, Nicholas K. [1 ]
机构：
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 11期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm2039
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.
引用
收藏
页码：833 / 846
页数：14
相关论文
共 50 条
  • [21] Receptor-type protein tyrosine phosphatases in cancertype protein tyrosine phosphatases in cancer
    Yu Du
    Jennifer RGrandis
    Chinese Journal of Cancer, 2015, 34 (02) : 61 - 69
  • [22] PROTEIN-TYROSINE PHOSPHATASES
    WALTON, KM
    DIXON, JE
    ANNUAL REVIEW OF BIOCHEMISTRY, 1993, 62 : 101 - 120
  • [23] Protein tyrosine phosphatases and signalling
    Stoker, AW
    JOURNAL OF ENDOCRINOLOGY, 2005, 185 (01) : 19 - 33
  • [24] Protein tyrosine phosphatases in autoimmunity
    Vang, Torkel
    Miletic, Ana V.
    Arimura, Yutaka
    Tautz, Lutz
    Rickert, Robert C.
    Mustelin, Tomas
    ANNUAL REVIEW OF IMMUNOLOGY, 2008, 26 : 29 - 55
  • [25] Protein tyrosine phosphatases in osteoclasts
    Granot-Attas, Shira
    Knobler, Hilla
    Elson, Ari
    CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2007, 17 (01): : 49 - 71
  • [26] CLONING OF PROTEIN TYROSINE PHOSPHATASES FROM MURINE BRAIN
    CHANTRY, D
    HUNTER, T
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 308 - 308
  • [27] Protein tyrosine phosphatases in signaling
    Streuli, M
    CURRENT OPINION IN CELL BIOLOGY, 1996, 8 (02) : 182 - 188
  • [28] PROTEIN-TYROSINE PHOSPHATASES
    STONE, RL
    DIXON, JE
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (50) : 31323 - 31326
  • [29] Protozoan protein tyrosine phosphatases
    Andreeva, Alexandra V.
    Kutuzov, Mikhail A.
    INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2008, 38 (11) : 1279 - 1295
  • [30] Protein tyrosine phosphatases and their inhibitors
    Dewang, PM
    Hsu, NM
    Peng, SZ
    Li, WR
    CURRENT MEDICINAL CHEMISTRY, 2005, 12 (01) : 1 - 22
12345