Protein tyrosine phosphatases: from genes, to function, to disease

被引：1269
作者：
Tonks, Nicholas K. [1 ]
机构：
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 11期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm2039
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.
引用
收藏
页码：833 / 846
页数：14
相关论文
共 133 条
  • [1] LKB1-dependent signaling pathways
    Alessi, Dario R.
    Sakamoto, Kei
    Bayascas, Jose R.
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 : 137 - 163
  • [2] Protein tyrosine phosphatases in the human genome
    Alonso, A
    Sasin, J
    Bottini, N
    Friedberg, I
    Friedberg, I
    Osterman, A
    Godzik, A
    Hunter, T
    Dixon, J
    Mustelin, T
    [J]. CELL, 2004, 117 (06) : 699 - 711
  • [3] Structural and evolutionary relationships among protein tyrosine phosphatase domains
    Andersen, JN
    Mortensen, OH
    Peters, GH
    Drake, PG
    Iversen, LF
    Olsen, OH
    Jansen, PG
    Andersen, HS
    Tonks, NK
    Moller, NPH
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (21) : 7117 - 7136
  • [4] A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage
    Andersen, JN
    Jansen, PG
    Echwald, SM
    Mortensen, OH
    Fukada, T
    Del Vecchio, R
    Tonks, NK
    Moller, NPH
    [J]. FASEB JOURNAL, 2004, 18 (01) : 8 - 30
  • [5] ANDERSEN JN, 2004, PROTEIN TYROSINE PHO
  • [6] Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase σ
    Aricescu, AR
    McKinnell, IW
    Halfter, W
    Stoker, AW
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (06) : 1881 - 1892
  • [7] Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma
    Azzedine, H
    Bolino, A
    Taïeb, T
    Birouk, N
    Di Duca, M
    Bouhouche, A
    Benamou, S
    Mrabet, A
    Hammadouche, T
    Chkili, T
    Gouider, R
    Ravazzolo, R
    Brice, A
    Laporte, J
    LeGuern, E
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) : 1141 - 1153
  • [8] Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase
    Begley, MJ
    Taylor, GS
    Brock, MA
    Ghosh, P
    Woods, VL
    Dixon, JE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (04) : 927 - 932
  • [9] The structure and regulation of myotubularin phosphatases
    Begley, MJ
    Dixon, JE
    [J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 2005, 15 (06) : 614 - 620
  • [10] A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    Begovich, AB
    Carlton, VEH
    Honigberg, LA
    Schrodi, SJ
    Chokkalingam, AP
    Alexander, HC
    Ardlie, KG
    Huang, QQ
    Smith, AM
    Spoerke, JM
    Conn, MT
    Chang, M
    Chang, SYP
    Saiki, RK
    Catanese, JJ
    Leong, DU
    Garcia, VE
    McAllister, LB
    Jeffery, DA
    Lee, AT
    Batliwalla, F
    Remmers, E
    Criswell, LA
    Seldin, MF
    Kastner, DL
    Amos, CI
    Sninsky, JJ
    Gregersen, PK
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (02) : 330 - 337
12345678910