Investigation of Solution-Mediated Phase Transformation of Cefuroxime Acid to Its Acetonitrile Solvate

被引：17
作者：
Wang, Guan [1 ]
Ma, Youguang [1 ]
Wang, Yongli [1 ,2 ]
Hao, Hongxun [1 ,2 ]
Jiang, Yang [3 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
[2] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
[3] Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2015年 / 19卷 / 12期
基金：
中国国家自然科学基金;
关键词：
SOLID-STATE TRANSFORMATIONS; CRYSTALLIZING DRUG PHASE; SITU RAMAN-SPECTROSCOPY; PLUS WATER MIXTURES; POLYMORPHIC TRANSFORMATION; IN-SITU; THEOPHYLLINE; ERYTHROMYCIN; NUCLEATION; KINETICS;
D O I：
10.1021/op500304u
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The cefuroxime acid and its acetonitrile solvate were characterized by using a series of methods, such as optical microscopy, powder X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, and Raman spectroscopy. The solvation profile of cefuroxime acid in acetonitrile and water mixture was determined at 303.15 K by phase transformation experiments. The solution-mediated phase transformation from cefuroxime acid to its acetonitrile solvate was in situ investigated with the help of Raman spectroscopy and PVM. It was found that the nucleation process of acetonitrile solvate was the limiting step of the transformation process. Furthermore, kinetic parameters of the transformation process at different temperatures were obtained using the Johnson-Mehl-Avrami equation. The influence of different operating parameters on the transformation process was also investigated to better understand the process.
引用
收藏
页码：1820 / 1825
页数：6
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