Bangladesh;
genotype;
1f;
hepatitis E virus;
HEV;
outbreak;
EPIDEMIOLOGY;
BURDEN;
D O I:
10.1002/jmv.26739
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Hepatitis E virus (HEV) infection is a significant public health issue in many developing countries, causing waterborne outbreaks as well as sporadic hepatitis. We report here an outbreak of HEV genotype 1f infection during April-May 2018 among people living at Halisohor, a low land in the southern part of Chottogram District of Bangladesh. A total of 933 patients were admitted to Combined Military Hospital (CMH), Chottogram, with symptoms of acute hepatitis. Among them, 550 patients were tested by ELISA for HEV-specific immunoglobulin A (IgM) and all were positive. Genotyping, sequencing, and phylogenetic analysis based on ORF2 region revealed that the outbreak was caused by genotype 1f and the strains were closely related to the previously reported HEV strains that caused the outbreak in Bangladesh in 2010. The current outbreak was most likely linked with water supply as fecal contamination in water was evident and could be prevented by ensuring access to safe drinking water.
机构:
Minist Hlth & Family Welf, Inst Epidemiol Dis Control & Res, Dhaka, BangladeshIcddr B, Dhaka, Bangladesh
Husain, Mushtuq
Ara, Khorshed
论文数: 0引用数: 0
h-index: 0
机构:
Minist Hlth & Family Welf, Inst Epidemiol Dis Control & Res, Dhaka, BangladeshIcddr B, Dhaka, Bangladesh
Ara, Khorshed
Jahan, Yasmin
论文数: 0引用数: 0
h-index: 0
机构:
Minist Hlth & Family Welf, Inst Epidemiol Dis Control & Res, Dhaka, BangladeshIcddr B, Dhaka, Bangladesh
Jahan, Yasmin
Rahman, Mahmudur
论文数: 0引用数: 0
h-index: 0
机构:
Minist Hlth & Family Welf, Inst Epidemiol Dis Control & Res, Dhaka, BangladeshIcddr B, Dhaka, Bangladesh
Rahman, Mahmudur
Luby, Stephen P.
论文数: 0引用数: 0
h-index: 0
机构:
Icddr B, Dhaka, Bangladesh
Ctr Dis Control & Prevent, Global Dis Detect Branch, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA USAIcddr B, Dhaka, Bangladesh
机构:
Erasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, NetherlandsErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
Wang, Wenshi
Bramer, Wichor M.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus MC Univ Med Ctr Rotterdam, Med Lib, Rotterdam, NetherlandsErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
Bramer, Wichor M.
Geng, Jiawei
论文数: 0引用数: 0
h-index: 0
机构:
First Peoples Hosp Yunnan Prov, Dept Infect Dis, Kunming, Peoples R ChinaErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
Geng, Jiawei
Huang, Fen
论文数: 0引用数: 0
h-index: 0
机构:
Kunming Univ Sci & Technol, Fac Med, Kunming, Peoples R ChinaErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
Huang, Fen
de Man, Robert A.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, NetherlandsErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
de Man, Robert A.
Peppelenbosch, Maikel P.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, NetherlandsErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
Peppelenbosch, Maikel P.
Pan, Qiuwei
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, NetherlandsErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
机构:
Minist Hlth & Family Welf, Inst Epidemiol Dis Control & Res, Dhaka, BangladeshIcddr B, Dhaka, Bangladesh
Husain, Mushtuq
Ara, Khorshed
论文数: 0引用数: 0
h-index: 0
机构:
Minist Hlth & Family Welf, Inst Epidemiol Dis Control & Res, Dhaka, BangladeshIcddr B, Dhaka, Bangladesh
Ara, Khorshed
Jahan, Yasmin
论文数: 0引用数: 0
h-index: 0
机构:
Minist Hlth & Family Welf, Inst Epidemiol Dis Control & Res, Dhaka, BangladeshIcddr B, Dhaka, Bangladesh
Jahan, Yasmin
Rahman, Mahmudur
论文数: 0引用数: 0
h-index: 0
机构:
Minist Hlth & Family Welf, Inst Epidemiol Dis Control & Res, Dhaka, BangladeshIcddr B, Dhaka, Bangladesh
Rahman, Mahmudur
Luby, Stephen P.
论文数: 0引用数: 0
h-index: 0
机构:
Icddr B, Dhaka, Bangladesh
Ctr Dis Control & Prevent, Global Dis Detect Branch, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA USAIcddr B, Dhaka, Bangladesh
机构:
Erasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, NetherlandsErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
Wang, Wenshi
Bramer, Wichor M.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus MC Univ Med Ctr Rotterdam, Med Lib, Rotterdam, NetherlandsErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
Bramer, Wichor M.
Geng, Jiawei
论文数: 0引用数: 0
h-index: 0
机构:
First Peoples Hosp Yunnan Prov, Dept Infect Dis, Kunming, Peoples R ChinaErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
Geng, Jiawei
Huang, Fen
论文数: 0引用数: 0
h-index: 0
机构:
Kunming Univ Sci & Technol, Fac Med, Kunming, Peoples R ChinaErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
Huang, Fen
de Man, Robert A.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, NetherlandsErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
de Man, Robert A.
Peppelenbosch, Maikel P.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, NetherlandsErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
Peppelenbosch, Maikel P.
Pan, Qiuwei
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, NetherlandsErasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands