Effects of Physical Exercise on Endothelial Function and DNA Methylation

被引:33
|
作者
Ferrari, Luca [1 ]
Vicenzi, Marco [1 ,2 ]
Tarantini, Letizia [1 ]
Barretta, Francesco [1 ,3 ]
Sironi, Silvia [1 ]
Baccarelli, Andrea A. [4 ]
Guazzi, Marco [5 ]
Bollati, Valentina [1 ]
机构
[1] Univ Milan, Dept Clin Sci & Community Hlth, Epidemiol Epigenet & Toxicol Lab, EPIGET, Via San Barnaba 8, I-20122 Milan, Italy
[2] Univ Milan, Dept Clin Sci & Community Hlth, Osped Maggiore Policlin, Dept Cardiol,Fdn IRCSS Ca Granda, Via San Barnaba 8, I-20122 Milan, Italy
[3] Fdn IRCCS Ist Nazl Tumori, Unit Clin Epidemiol & Trial Org, I-20133 Milan, Italy
[4] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY 10032 USA
[5] Univ Milan, IRCCS Policlin San Donato, Heart Failure Unit, Cardiol Univ Dept, I-20097 Milan, Italy
基金
欧洲研究理事会;
关键词
physical exercise; hypertension; DNA methylation; pyrosequencing; cardiovascular disease; NITRIC-OXIDE SYNTHASE; LIFE-STYLE MODIFICATION; CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; RISK-FACTORS; CARDIORESPIRATORY FITNESS; NONCOMMUNICABLE DISEASES; EPIGENETIC MODIFICATIONS;
D O I
10.3390/ijerph16142530
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Essential hypertension is the leading preventable cause of death in the world. Epidemiological studies have shown that physical training can reduce blood pressure ( BP), both in hypertensive and healthy individuals. Increasing evidence is emerging that DNA methylation is involved in alteration of the phenotype and of vascular function in response to environmental stimuli. We evaluated repetitive element and gene-specific DNA methylation in peripheral blood leukocytes of 68 volunteers, taken before ( T0) and after ( T1) a three-month intervention protocol of continuative aerobic physical exercise. DNA methylation was assessed by bisulfite-PCR and pyrosequencing. Comparing T0 and T1 measurements, we found an increase in oxygen consumption at peak of exercise ( VO2peak) and a decrease in diastolic BP at rest. Exercise increased the levels of ALU and Long Interspersed Nuclear Element 1 ( LINE-1) repetitive elements methylation, and of Endothelin-1 ( EDN1), Inducible Nitric Oxide Synthase ( NOS2), and Tumour Necrosis Factor Alpha ( TNF) gene-specific methylation. VO2peak was positively associated with methylation of ALU, EDN1, NOS2, and TNF; systolic BP at rest was inversely associated with LINE-1, EDN1, and NOS2 methylation; diastolic BP was inversely associated with EDN1 and NOS2 methylation. Our findings suggest a possible role of DNA methylation for lowering systemic BP induced by the continuative aerobic physical training program.
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页数:11
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